Cysteine proteases as potential targets for anti-trypanosomatid drug discovery
| Autor: | Tiago Rodrigues, Fábio da Silva Siqueira, Luan dos Santos Vianna, Letícia S. Ferraz, Maurício F.M. Machado, Rayssa de Mello Lopes, Taiz dos Reis Santos, Mariana Nascimento Romero Trujilho, Wagner Alves de Souza Judice, Laura de Azevedo Maffeis Dalzoto, Juliana F. Di Iorio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Proteases
Trypanosoma Clinical Biochemistry Pharmaceutical Science Drug resistance Computational biology Cysteine Proteinase Inhibitors Biochemistry Parasitic Sensitivity Tests Cysteine Proteases Trypanosomiasis Drug Discovery medicine Humans Molecular Biology Leishmaniasis Leishmania biology Molecular Structure Drug discovery Chemistry Organic Chemistry Neglected Disease medicine.disease biology.organism_classification Trypanocidal Agents Molecular Medicine Cysteine |
| Zdroj: | Bioorganicmedicinal chemistry. 46 |
| ISSN: | 1464-3391 |
| Popis: | Leishmaniasis and trypanosomiasis are endemic neglected disease in South America and Africa and considered a significant public health problem, mainly in poor communities. The limitations of the current available therapeutic options, including the lack of specificity, relatively high toxicity, and the drug resistance acquiring, drive the constant search for new targets and therapeutic options. Advances in knowledge of parasite biology have revealed essential enzymes involved in the replication, survival, and pathogenicity of Leishmania and Trypanosoma species. In this scenario, cysteine proteases have drawn the attention of researchers and they are being proposed as promising targets for drug discovery of antiprotozoal drugs. In this systematic review, we will provide an update on drug discovery strategies targeting the cysteine proteases as potential targets for chemotherapy against protozoal neglected diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect