Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress
| Autor: | Solmaz Nasseri Maleki, Yaser Azizi, Nahid Aboutaleb, Sohaila Erfani, Kamran Rakhshan, Faramarz Souri |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cardiotonic Agents Interleukin-1beta Immunology Anti-Inflammatory Agents Myocardial Infarction Ischemia Apoptosis Inflammation Lavender oil Pharmacology medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oils Volatile medicine Animals Plant Oils Pharmacology (medical) Myocardial infarction Rats Wistar TUNEL assay Tumor Necrosis Factor-alpha business.industry Glutathione medicine.disease Interleukin-10 Rats Oxidative Stress Lavandula 030104 developmental biology chemistry Tumor necrosis factor alpha medicine.symptom business Biomarkers 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Inflammopharmacology. 27:799-807 |
| ISSN: | 1568-5608 0925-4692 |
| DOI: | 10.1007/s10787-018-0520-y |
| Popis: | The study was conducted to examine therapeutic effects of lavender oil (LO) against myocardial infarction (MI) and its potential mechanisms. A rat model of MI was established and LO (100, 200 and 300 mg/kg) was intraperitoneally administrated immediately after ischemia. Anti-inflammatory and antioxidant activity of LO were evaluated by immunohistochemical assay and measurement of SOD, GSH, and MDA. The myocardial injury markers, apoptotic activity and infarct volume were examined by ELISA, TUNEL and TTC staining, respectively. Compared with the control I/R-Vehicle, the expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) significantly reduced 8 h after reperfusion and expression of interleukin-10 (IL-10) elevated 48 h after reperfusion in LO-treated rats (P |
| Databáze: | OpenAIRE |
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