Severe mitochondrial anomaly in dystrophic mouse skeletal muscle
| Autor: | Brigitte Lucas-Heron, Marie-Jeanne Loirat, Béatrice Ollivier |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
General Neuroscience Muscles Calcium-Binding Proteins Dystrophic muscle Skeletal muscle Dystrophy Mitochondrion Biology Muscular Dystrophy Animal Mitochondria Muscle Mice Inbred C57BL Molecular Weight Mice medicine.anatomical_structure Enzyme Biochemistry chemistry Mole medicine NADH cytochrome C reductase biology.protein Cytochrome c oxidase Animals Subcellular Fractions |
| Zdroj: | Neuroscience letters. 90(1-2) |
| ISSN: | 0304-3940 |
| Popis: | Mitochondrial fractions were isolated from skeletal muscle of control (C57 BL 6J dy/+) and dystrophic (C57 BL 6J dy/dy) mice, and enzymatic activities (cytochrome c oxidase, rotenone-insensitive NADH cytochrome c reductase) were determined. After electrophoretic separation, calcium-binding proteins were identified. An important anomaly was observed in the mitochondria of dystrophic muscle, i.e., a considerable reduction of a specific calcium-binding protein (61,000 Da mol. wt.). |
| Databáze: | OpenAIRE |
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