Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin
| Autor: | J. R. Shelton, R Phillips, Walter A. Schroeder, M Gravely, Joan Balog Shelton, Titus H.J. Huisman, Ha Minh Lam, Georgi D. Efremov, A Reese, J M Harrison |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Cord Chemical Phenomena Globulin Hereditary persistence of fetal hemoglobin Hemoglobins Abnormal Thalassemia Physiology Anemia Sickle Cell Biology Fetal hemoglobin medicine Humans Fetal Hemoglobin Racial Groups Infant Newborn General Medicine Fetal Blood medicine.disease Sickle cell anemia Pedigree Chemistry Human fetal Immunology biology.protein Female Hemoglobin Research Article |
| Zdroj: | Journal of Clinical Investigation. 63:268-275 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci109299 |
| Popis: | A further study of the Tgamma-chain in a variety of conditions has revealed its presence in the cord bloods of ethnic groups previously unstudied. Heterozygous newborn average 17-19% Tgamma-chain while the mean value in four presumed homozygotes was 31%. The Tgamma-chain is readily detectable in beta-thalassemia of various ethnic groups (although infrequent in Blacks) as well as in deltabeta-thalassemia. Studies of a few families have provided an opportunity to determine whether or not certain individuals are heterozygous or homozygous for the Tgamma-gene. The Tgamma-chain has not been detected in the human fetal hemoglobin that is synthesized in increased amounts in persons with the hereditary persistence of fetal hemoglobin. Although the Tgamma-chain is detectable in sickle cell anemia, its frequency appears to be lower than in normal individuals. By focusing upon the relationship of the percentage of Tgamma-chain to the sources of human fetal globulin from determinants in cis and in trans, the conclusion has been reached that the Tgamma-chain is the product of a mutant Agamma-locus which should be named the TAgamma-chain. |
| Databáze: | OpenAIRE |
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