Clinical relevance of reduced decorrelation signals in the diabetic inner choroid on optical coherence tomography angiography
| Autor: | Masahiro Fujimoto, Shin Yoshitake, Tatsuya Yoshitake, Yoko Dodo, Kenji Ishihara, Kiyoshi Suzuma, Yuko Miwa, Tomoaki Murakami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Visual acuity genetic structures Science Visual Acuity Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Humans Medicine Clinical significance Fluorescein Angiography Aged Retrospective Studies Diabetic Retinopathy Multidisciplinary medicine.diagnostic_test Choroid business.industry Retinal Vessels Retinal Optical coherence tomography angiography Diabetic retinopathy Blood flow Middle Aged medicine.disease Fluorescein angiography eye diseases Retinal diseases 030104 developmental biology medicine.anatomical_structure chemistry Case-Control Studies 030221 ophthalmology & optometry Female Radiology sense organs Medical imaging medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Diabetes induces lesions of the retinal and choroidal capillaries, which promote the pathogenesis of diabetic retinopathy (DR). The decorrelation signals in optical coherence tomography angiography (OCTA) represent the blood flow and vascular structure, and three-dimensional OCTA images enable individual capillary layers to be evaluated separately. The current study documented that en-face OCTA images revealed spots of flow void in the choriocapillaris layer in eyes with DR. Quantitative investigation demonstrated that non-flow areas within the central subfield (CSF) increased in eyes with more severe DR grades. The non-flow areas in the choriocapillaris layer were also associated with poorer visual acuity (VA) in all 108 eyes. A modest correlation was noted between the areas of flow void and poorer VA in 69 eyes without DME, whereas the non-flow areas were not related to VA or to CSF thickness measured by OCT in 39 eyes with DME. In 12 eyes with ischemic maculopathy, the choriocapillaris layer beneath the disrupted ellipsoid zone of the photoreceptor (EZ) had greater areas of flow void than did the area beneath an intact EZ. These data suggested that disrupted choroidal circulation has clinical relevance and contributes to the pathogenesis of DR. |
| Databáze: | OpenAIRE |
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