Skewed Distribution of IL-7 Receptor-α-Expressing Effector Memory CD8+ T Cells with Distinct Functional Characteristics in Oral Squamous Cell Carcinoma

Autor: Ching Wen Chen, Chiau-Jing Jung, Yen Liang Chang, Jang-Jaer Lee, Jean-San Chia, Chia Ju Yang, Shih-Jung Cheng, Jenq-Yuh Ko, Hui-Yi Lin, Chiou Yueh Yeh, Hui Ming Yu, Du Mao-Kuang, Andy Sun
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Apoptosis
CD8-Positive T-Lymphocytes
Interleukin 21
Oral Diseases
immune system diseases
Tumor Cells
Cultured
Cytotoxic T cell
IL-2 receptor
Multidisciplinary
T Cells
ZAP70
virus diseases
hemic and immune systems
Natural killer T cell
Head and Neck Tumors
Cell biology
medicine.anatomical_structure
Oncology
Carcinoma
Squamous Cell
Disease Progression
Medicine
Mouth Neoplasms
circulatory and respiratory physiology
Research Article
Tumor Immunology
Receptors
CCR7
Science
T cell
Immune Cells
Oral Medicine
chemical and pharmacologic phenomena
Biology
Immunomodulation
Interleukin-7 Receptor alpha Subunit
Interferon-gamma
medicine
Cancer Detection and Diagnosis
Humans
Antigen-presenting cell
Interleukin 3
Cell Proliferation
Cancers and Neoplasms
Immunologic Subspecialties
Molecular biology
Case-Control Studies
Interleukin-2
Leukocyte Common Antigens
Clinical Immunology
Immunologic Memory
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e85521 (2014)
ISSN: 1932-6203
Popis: CD8(+) T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8(+) T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7(-)CD45RA(-)CD8(+) T cells and CCR7(-) CD45RA(+)CD8(+) T cells negatively correlated with each other. A significantly higher frequency of CD127(lo) CCR7(-)CD45RA(-)CD8(+) T cells or CCR7(-)CD45RA(+)CD8(+) T cells among total CD8(+) T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127(hi) CCR7(-)CD45RA(-)CD8(+) T cells or CCR7(-)CD45RA(+)CD8(+) T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127(lo) CCR7(-)CD45RA(-)CD8(+) T cells or CCR7(-)CD45RA(+)CD8(+) T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7(-)CD45RA(+)CD8(+) T cells to CCR7(-)CD45RA(-)CD8(+) T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127(lo) CCR7(-)CD45RA(-)CD8(+) T cells and CCR7(-)CD45RA(+)CD8(+) T cells are functionally similar CD8(+) T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8(+) effector memory balance toward CCR7(-)CD45RA(+)CD8(+) T cells is associated with OSCC progression.
Databáze: OpenAIRE
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