Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study
| Autor: | Priyanka Chandratre, Jane C Richardson, Sara Muller, James A. Prior, Christian D Mallen, Edward Roddy |
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| Rok vydání: | 2016 |
| Předmět: |
Male
musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Gout Allopurinol Comorbidity Anxiety Gout Suppressants 03 medical and health sciences 0302 clinical medicine Rheumatology Surveys and Questionnaires Internal medicine Prevalence Humans Medicine Prospective Studies 030212 general & internal medicine Prospective cohort study Depression (differential diagnoses) Aged 030203 arthritis & rheumatology Primary Health Care Depression business.industry nutritional and metabolic diseases Odds ratio Middle Aged Primary care medicine.disease United Kingdom Patient Health Questionnaire Physical therapy Female medicine.symptom business RA medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1297-319X 1778-7254 |
| Popis: | Objectives To determine the prevalence of anxiety and depression in gout, examine associations between gout characteristics and these comorbidities and determine the role of allopurinol in any such relationships. Method As part of a prospective cohort study, a baseline questionnaire was sent to 1805 participants with gout aged ≥ 18 years from UK primary care. Participants had a gout diagnosis or prescriptions for allopurinol or colchicine in their medical records 2 years prior to baseline. Prevalence of anxiety was defined using the Generalised Anxiety Disorder questionnaire and depression using the Patient Health Questionnaire. Logistic regression was used to examine any association between gout characteristics (12-month attack frequency, oligo/polyarticular gout and gout duration) and the presence of anxiety or depression. Crude and adjusted associations were reported as odds ratios (OR) and 95% confidence intervals (CI). Adjusted gout characteristics were stratified by allopurinol use. Results One thousand one hundred and eighty-four participants responded to baseline (65.6%). Prevalence of anxiety and depression were 10.0% and 12.6% respectively. There was no association between gout characteristics and anxiety. However, there was an association between attack frequency and depression amongst those gout patients using allopurinol (2.87 [1.2 to 6.6]) and also between oligo/polyarticular gout and depression (2.01 [1.2 to 3.3]), irrespective of allopurinol use (2.09 [1.1 to 4.0]) or not (2.64 [1.0 to 6.8]). Conclusion Patients experiencing frequent gout attacks or attacks in multiple joints are likely to experience depressive symptoms, even when using allopurinol. Depression may influence medication adherence and participation in routine reviews, hence impacting adversely on gout management outcomes. |
| Databáze: | OpenAIRE |
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