Toward improved endoscopic surveillance with multidiameter single fiber reflectance spectroscopy in patients with Barrett's esophagus
| Autor: | Kiki Fockens, Roos E. Pouw, Albert J. de Groof, Jacques J. Bergman, Dirk J. Faber, Anouk L. Post, Bas L.A.M. Weusten, Xu U. Zhang, Daniel M. de Bruin, Henricus J. C. M. Sterenborg, Ton G. van Leeuwen, Anne-Fré Swager, Wouter L. Curvers |
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| Přispěvatelé: | Gastroenterology and hepatology, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Graduate School, Biomedical Engineering and Physics, Urology, APH - Personalized Medicine, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, ACS - Atherosclerosis & ischemic syndromes |
| Rok vydání: | 2021 |
| Předmět: |
spectroscopy
medicine.medical_specialty esophageal adenocarcinoma Esophageal Neoplasms Reflectance spectroscopy Single fiber General Physics and Astronomy 01 natural sciences General Biochemistry Genetics and Molecular Biology 010309 optics Barrett Esophagus SFR 0103 physical sciences medicine Humans General Materials Science endoscopy Oral mucosa Esophagus multidiameter SFR medicine.diagnostic_test business.industry Barrett' esophagus Spectrum Analysis 010401 analytical chemistry General Engineering General Chemistry Esophageal cancer medicine.disease digestive system diseases 0104 chemical sciences Endoscopy medicine.anatomical_structure Barrett's esophagus Field cancerization Esophagoscopy Radiology business |
| Zdroj: | Journal of biophotonics, 14(4):e202000351. Wiley-VCH Verlag Post, A L, de Groof, A J, Zhang, X U, Swager, A-F, Fockens, K N, Pouw, R E, Weusten, B L A M, Faber, D J, de Bruin, D M, Bergman, J J G H M, van Leeuwen, T G, Sterenborg, H J C M & Curvers, W L 2021, ' Toward improved endoscopic surveillance with multidiameter single fiber reflectance spectroscopy in patients with Barrett's esophagus ', Journal of biophotonics, vol. 14, no. 4, e202000351 . https://doi.org/10.1002/jbio.202000351 |
| ISSN: | 1864-0648 1864-063X |
| DOI: | 10.1002/jbio.202000351 |
| Popis: | Patients with Barrett's esophagus are at an increased risk to develop esophageal cancer and, therefore, undergo regular endoscopic surveillance. Early detection of neoplasia enables endoscopic treatment, which improves outcomes. However, early Barrett's neoplasia is easily missed during endoscopic surveillance. This study investigates multidiameter single fiber reflectance spectroscopy (MDSFR) to improve Barrett's surveillance. Based on the concept of field cancerization, it may be possible to identify the presence of a neoplastic lesion from measurements elsewhere in the esophagus or even the oral cavity. In this study, MDSFR measurements are performed on non-dysplastic Barrett's mucosa, squamous mucosa, oral mucosa, and the neoplastic lesion (if present). Based on logistic regression analysis on the scattering parameters measured by MDSFR, a classifier is developed that can predict the presence of neoplasia elsewhere in the Barrett's segment from measurements on the non-dysplastic Barrett's mucosa (sensitivity 91%, specificity 71%, AUC = 0.77). Classifiers obtained from logistic regression analysis for the squamous and oral mucosa do not result in an AUC significantly different from 0.5. |
| Databáze: | OpenAIRE |
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