Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel
| Autor: | Baris Turkbey, Lori Mankowski Gettle, Juliana B. Starcevich, Bryan R. Foster, Chan Kyo Kim, Christopher A. Warlick, Jinxing Yu, Jurgen J. Fütterer, Fergus V. Coakley, Ronald J. Zagoria, Adam T. Froemming, Sadhna Verma, John F. Ward, Sandeep Arora, Thomas J. Polascik, Silvia D. Chang, Steven C. Eberhardt, Samir S. Taneja, Charles E. McCulloch, Peter A. Pinto, Aytekin Oto, Candice Kim, Michael T. Booker, Leonardo Kayat Bittencourt, Andrew R. Weinberger, Mark R. Gertner, David D. Casalino, Rosaleen B. Parsons, Peter R. Carroll, Michael E. Hahn, Jordan Anaokar, Roozbeh Houshyar, Vaughn Braxton, Nimrod S. Barashi, Dhakshina Ganeshan, Andrew B. Rosenkrantz, Ravjot Dhatt, Antonio C. Westphalen, Nayana U. Patel, Stephen E. McRae, Tharakeswara K. Bathala, Rajan T. Gupta, Benjamin Spilseth, Sangeet Ghai, Chandana Lall, Daniel Margolis, Varaha S. Tammisetti, Jelle O. Barentsz |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Urologic Diseases medicine.medical_specialty Aging Cross-sectional study Medical and Health Sciences 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Interquartile range Prostate Predictive Value of Tests Clinical Research Medical medicine Humans Radiology Nuclear Medicine and imaging Societies Medical Original Research Retrospective Studies Aged Cancer screening and diagnosis business.industry Prostate Cancer Prevention Prostatic Neoplasms Reproducibility of Results Retrospective cohort study medicine.disease Magnetic Resonance Imaging Confidence interval PI-RADS Detection Nuclear Medicine & Medical Imaging medicine.anatomical_structure Cross-Sectional Studies Radiology Information Systems Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] 030220 oncology & carcinogenesis Predictive value of tests Biomedical Imaging Radiology business Societies 4.2 Evaluation of markers and technologies |
| Zdroj: | Radiology, vol 296, iss 1 Radiology, 296, 76-84 Radiology Radiology, 296, 1, pp. 76-84 |
| ISSN: | 0033-8419 |
| Popis: | Item does not contain fulltext Background Prostate MRI is used widely in clinical care for guiding tissue sampling, active surveillance, and staging. The Prostate Imaging Reporting and Data System (PI-RADS) helps provide a standardized probabilistic approach for identifying clinically significant prostate cancer. Despite widespread use, the variability in performance of prostate MRI across practices remains unknown. Purpose To estimate the positive predictive value (PPV) of PI-RADS for the detection of high-grade prostate cancer across imaging centers. Materials and Methods This retrospective cross-sectional study was compliant with the HIPAA. Twenty-six centers with members in the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel submitted data from men with suspected or biopsy-proven untreated prostate cancer. MRI scans were obtained between January 2015 and April 2018. This was followed with targeted biopsy. Only men with at least one MRI lesion assigned a PI-RADS score of 2-5 were included. Outcome was prostate cancer with Gleason score (GS) greater than or equal to 3+4 (International Society of Urological Pathology grade group >/=2). A mixed-model logistic regression with institution and individuals as random effects was used to estimate overall PPVs. The variability of observed PPV of PI-RADS across imaging centers was described by using the median and interquartile range. Results The authors evaluated 3449 men (mean age, 65 years +/- 8 [standard deviation]) with 5082 lesions. Biopsy results showed 1698 cancers with GS greater than or equal to 3+4 (International Society of Urological Pathology grade group >/=2) in 2082 men. Across all centers, the estimated PPV was 35% (95% confidence interval [CI]: 27%, 43%) for a PI-RADS score greater than or equal to 3 and 49% (95% CI: 40%, 58%) for a PI-RADS score greater than or equal to 4. The interquartile ranges of PPV at these same PI-RADS score thresholds were 27%-44% and 27%-48%, respectively. Conclusion The positive predictive value of the Prostate Imaging and Reporting Data System was low and varied widely across centers. (c) RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Milot in this issue. |
| Databáze: | OpenAIRE |
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