Crossed Cerebellar Diaschisis Indicates Hemodynamic Compromise in Ischemic Stroke Patients

Autor: Martina Sebök, Susanne Wegener, Christoph Stippich, Jorn Fierstra, Mohamad El Amki, Lita von Bieberstein, Andreas R. Luft, Marco Piccirelli, Christiaan Hendrik Bas van Niftrik, Luca Regli
Přispěvatelé: University of Zurich, Wegener, Susanne
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Neurology
Hemodynamics
030218 nuclear medicine & medical imaging
Brain Ischemia
Cohort Studies
0302 clinical medicine
Cerebellar hemisphere
Cerebellum
Prospective Studies
Stroke
Aged
80 and over
General Neuroscience
2800 General Neuroscience
Middle Aged
Magnetic Resonance Imaging
2728 Neurology (clinical)
Cardiology
Original Article
Female
Neurosurgery
Internal carotid artery
Cardiology and Cardiovascular Medicine
Carotid Artery
Internal
Adult
medicine.medical_specialty
610 Medicine & health
Posterior cerebral artery
2705 Cardiology and Cardiovascular Medicine
10180 Clinic for Neurosurgery
03 medical and health sciences
Oxygen Consumption
10043 Clinic for Neuroradiology
Duplex sonography
medicine.artery
Internal medicine
medicine
Humans
Aged
Ischemic Stroke
Cerebrovascular reserve
business.industry
urogenital system
Blood flow
medicine.disease
equipment and supplies
10040 Clinic for Neurology
Neurology (clinical)
Crossed cerebellar diaschisis
BOLD MRI
business
030217 neurology & neurosurgery
ICA occlusion
Zdroj: Translational Stroke Research
ISSN: 1868-601X
1868-4483
Popis: Crossed cerebellar diaschisis (CCD) in internal carotid artery (ICA) stroke refers to attenuated blood flow and energy metabolism in the contralateral cerebellar hemisphere. CCD is associated with an interruption of cerebro-cerebellar tracts, but the precise mechanism is unknown. We hypothesized that in patients with ICA occlusions, CCD might indicate severe hemodynamic impairment in addition to tissue damage. Duplex sonography and clinical data from stroke patients with unilateral ICAO who underwent blood oxygen-level-dependent MRI cerebrovascular reserve (BOLD-CVR) assessment were analysed. The presence of CCD (either CCD+ or CCD−) was inferred from BOLD-CVR. We considered regions with negative BOLD-CVR signal as areas suffering from hemodynamic steal. Twenty-five patients were included (11 CCD+ and 14 CCD−). Stroke deficits on admission and at 3 months were more severe in the CCD+ group. While infarct volumes were similar, CCD+ patients had markedly larger BOLD steal volumes than CCD− patients (median [IQR] 122.2 [111] vs. 11.6 [50.6] ml; p
Databáze: OpenAIRE
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