Diffusion kurtosis imaging and diffusion-weighted imaging in assessment of liver fibrosis stage and necroinflammatory activity
| Autor: | Yan Hong Xie, Meng Su Zeng, Kai Pu Jin, Li Yang, Cai Zhong Chen, He Qing Wang, Ruo Fan Sheng |
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| Rok vydání: | 2016 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Urology Liver fibrosis 030218 nuclear medicine & medical imaging Necrosis 03 medical and health sciences 0302 clinical medicine Fibrosis Image Interpretation Computer-Assisted medicine Animals Effective diffusion coefficient Radiology Nuclear Medicine and imaging Stage (cooking) Diffusion Kurtosis Imaging Radiological and Ultrasound Technology business.industry Gastroenterology medicine.disease Rats Disease Models Animal Diffusion Magnetic Resonance Imaging 030220 oncology & carcinogenesis Radiology business Hepatic fibrosis Nuclear medicine Diffusion MRI |
| Zdroj: | Abdominal Radiology. 42:1176-1182 |
| ISSN: | 2366-0058 2366-004X |
| DOI: | 10.1007/s00261-016-0984-4 |
| Popis: | To investigate and compare the diagnostic value of diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI) in assessing and quantifying hepatic fibrosis. Thirty rats were divided into the control group (n = 6) and the fibrosis experimental groups (n = 6 per group) with CCl4 administration for 2, 4, 6, and 8 weeks. Liver fibrosis stage (S) and necroinflammatory activity grade (G) were histopathologically determined. DKI and DWI were performed; mean apparent diffusion (MD), mean kurtosis (MK), and apparent diffusion coefficient (ADC) values were calculated. DKI parameters were compared with ADC values according to G/S scores. Strong inverse correlations were found between the degree of fibrosis and both MD and ADC (r = −0.840 and r = −0.760), while only weak correlation existed in MK (r = 0.405). ROC analyses demonstrated the AUC in MD, MK, and ADC of 0.862, 0.684, 0.817 for identifying mild and severe fibrosis, and 0.757, 0.675, 0.733 for non-cirrhosis and cirrhosis, respectively. The degree of fibrosis was significantly correlated with α-smooth muscle actin (α-SMA) (P |
| Databáze: | OpenAIRE |
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