Studies on calciferol metabolism II. Tritium loss from tritiated vitamin D3 and the possible structure of the proposed nuclear regulator of intestinal calcium transport
| Autor: | James F. Myrtle, Anthony W. Norman |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Vitamin Time Factors Chemical Phenomena Metabolite medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Calcium Kidney Tritium Biochemistry Bone and Bones Steroid chemistry.chemical_compound Endocrinology Intestine Small polycyclic compounds medicine Animals Molecular Biology Cholecalciferol Pharmacology Carbon Isotopes Chromatography Organic Chemistry Radiochemistry Biological Transport Biological activity Metabolism Vitamin D Deficiency Diet Hindlimb Rats Chemistry Cholesterol chemistry Chickens |
| Zdroj: | Steroids. 17:619-630 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(71)90078-x |
| Popis: | Cholecalciferol (vitamin D3) is rapidly metabolized, via a 25-hydroxy intermediate, to an as yet unidentified polar compound. This compound, designated Metabolite 4B, has previously been shown to be the most potent and rapidly-acting form of cholecalciferol yet found, and probably represents the biologically active form of this steroid in the intestine. Studies on the metabolism of a mixed dose of 1, 2-H-and 4-14C-labeled cholecalciferol in the rachitic chick reveal a loss of tritium in the formation of Metabolite 4B. The tritium loss involves the removal of a single hydrogen from the carbon-1 position. The implications of this tritium loss on the possible structure of Metabolite 4B are discussed. |
| Databáze: | OpenAIRE |
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