VITAMIN D DEFICIENCY AMONG INFLAMMATORYBOWEL DISEASE PATIENTS IN ARGENTINA: A CROSS-SECTIONAL STUDY
| Autor: | Maria Constanza Torella, Juan S. Lasa, Ignacio Zubiaurre, Astrid Rausch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Crohn’s disease medicine.medical_specialty Doença de Crohn Vitamina D Argentina Disease Severity of Illness Index Inflammatory bowel disease Statistics Nonparametric vitamin D deficiency Young Adult 03 medical and health sciences 0302 clinical medicine Crohn Disease Risk Factors Internal medicine Severity of illness Prevalence medicine Vitamin D and neurology Humans lcsh:RC799-869 Vitamin D Aged Cholecalciferol Crohn's disease Colite ulcerativa business.industry Gastroenterology Case-control study Middle Aged Vitamin D Deficiency medicine.disease Ulcerative colitis Cross-Sectional Studies Case-Control Studies Multivariate Analysis lcsh:Diseases of the digestive system. Gastroenterology Colitis Ulcerative Female 030211 gastroenterology & hepatology business 030215 immunology |
| Zdroj: | Arquivos de Gastroenterologia v.55 n.3 2018 Arquivos de gastroenterologia Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia instacron:IBEPEGE Arquivos de Gastroenterologia, Vol 55, Iss 3, Pp 216-220 |
| Popis: | BACKGROUND: An association has been established between low serum values of vitamin D and inflammatory bowel disease. There is a lack of evidence on whether this association is still observed in regions where sun exposure throughout the year is higher. OBJECTIVE: To compare the prevalence of vitamin D deficiency between inflammatory bowel disease patients and healthy controls. METHODS: Inflammatory bowel disease patients were consecutively enrolled as cases. Age and gender-matched healthy subjects who agreed to undertake a determination of serum vitamin D were enrolled as controls. Demographic features, medical treatment, need for hospital admission at diagnosis, steroid treatment, smoking, need for surgical treatment were evaluated as factors associated with vitamin D deficiency. RESULTS: Overall, 59 patients with a diagnosis of either Crohn’s disease or ulcerative colitis were enrolled, as well as 56 controls. Median age was 41 years (19-79) and 56% were male. Vitamin D deficiency was observed in 66.1% of inflammatory bowel disease patients versus 21.42% of healthy controls (OR 7.15 (3.1-16.48), P=0.001). Among inflammatory bowel disease patients, male gender, disease duration, moderate-to-severe disease and hospital admission at the moment of diagnosis were found to be associated with vitamin D deficiency. On multivariate analysis, only longer disease duration [(OR 1.01 (1-1.06)] and hospital admission at diagnosis [(OR 5.63 (1.01-31.61)] were found to be significantly associated with the latter. CONCLUSION: Vitamin D deficiency was more frequent among inflammatory bowel disease patients. Longer disease duration and need for hospital admission at diagnosis were associated to vitamin D deficiency among these patients. |
| Databáze: | OpenAIRE |
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