Serum elastin peptides in the preoperative evaluation of abdominal aortic aneurysms
| Autor: | Lene Heickendorff, R.A.P. Scott, H.A. Ashton, Jes S. Lindholt |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Surveillance Aortic Rupture macromolecular substances Preoperative care Sensitivity and Specificity Aortic aneurysm Aneurysm Predictive Value of Tests Preoperative Care medicine Humans cardiovascular diseases Aortic rupture Aged Medicine(all) Rupture Aged 80 and over biology business.industry medicine.disease Surgery Elastin ROC Curve Elastin peptides Predictive value of tests biology.protein cardiovascular system Biological Markers Female Cardiology and Cardiovascular Medicine business Abdominal aortic aneurysms Peptides Biomarkers Abdominal surgery Aortic Aneurysm Abdominal |
| Zdroj: | Lindholt, J S, Ashton, H A, Heickendorff, L & Scott, R A 2001, ' Serum elastin peptides in the preoperative evaluation of abdominal aortic aneurysms ' European Journal of Vascular and Endovascular Surgery, vol. 22, no. 6, pp. 546-50 . https://doi.org/10.1053/ejvs.2001.1516 Lindholt, J S, Ashton, H A, Heickendorff, L & Scott, R A 2001, ' Serum elastin peptides in the preoperative evaluation of abdominal aortic aneurysms ', European Journal of Vascular and Endovascular Surgery, vol. 22, no. 6, pp. 546-550 . |
| ISSN: | 1078-5884 |
| DOI: | 10.1053/ejvs.2001.1516 |
| Popis: | Objective: serum elastin peptides (SEP) have been reported to be associated with the expansion of small abdominal aortic aneurysms (AAA). Consequently, SEP-measurements may predict future rupture, and allow further selection for surgery in cases referred for surgery due to size. Material and methods: SEP was measured in 90 men and 10 women with AAA, who were considered for surgery as part of the Chichester aneurysm screening programme. Sixty-one patients were electively operated and four because of symptoms. The rest were followed up further. Twelve of these experienced ruptured AAA later. Results: no correlation between last measured AAA-diameter, annual expansion rate and SEP was noticed. However, SEP levels were significantly higher in cases rupturing later, persisting after adjustment for age, sex, and last measured AAA-size. ROC curve analysis concerning SEP as a predictor of rupture later showed an optimal sensitivity and specificity of 67% and 60%, respectively, similar with last measured AAA-size. By combining AAA-size and SEP, the optimal sensitivity and specificity reached 83% and 66%, respectively. Conclusion: one sampling of SEP combined with AAA-size in patients referred for AAA surgery may be a clinical useful indicator of high rupture risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect