Surface antigen expression on peripheral blood monocytes in women with gynecologic malignancies
| Autor: | Osazee E Okungbowa, Piotr Radziwon, Marzena Smoktunowicz, Alina Lipska, Marcin Jóźwik, Maciej Jóźwik, Andrzej Semczuk, Michał Jóźwik |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Neutrophils Uterine Cervical Neoplasms Gastroenterology Monocytes Immunophenotyping Diagnosis Differential Leukocyte Count Antigen Endometrial cancer Surface antigens Ovarian cancer Internal medicine Genetics medicine Humans Lymphocytes Neutrophil to lymphocyte ratio Aged Cervical cancer Aged 80 and over Ovarian Neoplasms business.industry Monocyte Cancer HLA-DR Antigens Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Endometrial Neoplasms Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Antigens Surface Female business Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background Of many specialized blood cells, monocytes are gaining increasing attention for their role in neoplastic disorders. The purpose of the present investigation was to determine the expression of selected peripheral blood monocyte surface antigens in cases of cervical, endometrial, and ovarian cancers. In addition, our aim was to validate the diagnostic value of two artificial coefficients recently proposed for the diagnosis of gynecologic malignancies: Neutrophil to Lymphocyte Ratio (NLR), and Multiplication of Neutrophil and Monocyte Counts (MNM). Methods We studied 69 white Caucasian women with histopathologic confirmation of endometrial (N = 42), cervical (N = 13), and ovarian (N = 14) cancers. Reference Group I were women suspected of cancer but histologically nullified (N = 20), and Group II were healthy blood donors (N = 23). Expression of CD11a, CD11b, CD11c, CD16, CD54 (ICAM-1), CD62 L (L-selectin), CD64, and HLA-DR was measured with immunofluorescence in a flow cytometer. Results CD54 expression increased by ≥35.6% (p |
| Databáze: | OpenAIRE |
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