Long-term outcome after sequential liver and lung metastasectomy is comparable to outcome of isolated liver or lung metastasectomy in colorectal carcinoma
Autor: | Jari Räsänen, Pauliina Reijonen, Jari Rantonen, Antti Kivelä, Anne Juuti, Helena Isoniemi, Jarmo A. Salo, Arno Nordin |
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Přispěvatelé: | HUS Abdominal Center, Helsinki University Hospital Area, Clinicum, II kirurgian klinikka, Department of Surgery, HUS Heart and Lung Center, III kirurgian klinikka, IV kirurgian klinikka |
Rok vydání: | 2019 |
Předmět: |
Male
Lung Neoplasms Time Factors Lung resections Colorectal cancer Liver resections Gastroenterology Metastasis Liver metastases 0302 clinical medicine Disseminated disease Pneumonectomy Isolated liver Aged 80 and over Liver Neoplasms SURGICAL RESECTION respiratory system Middle Aged Word count: 206 Prognosis 3. Good health Survival Rate medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis SURVIVAL 030211 gastroenterology & hepatology Female Metastasectomy Colorectal Neoplasms Lung metastases Adult medicine.medical_specialty 3122 Cancers HEPATIC RESECTION 03 medical and health sciences Colorectal metastases Internal medicine medicine KRAS MANAGEMENT Hepatectomy Humans CANCER PATIENTS Aged Retrospective Studies Lung business.industry PULMONARY METASTASES MUTATIONS medicine.disease 3126 Surgery anesthesiology intensive care radiology respiratory tract diseases Surgery business Follow-Up Studies |
Zdroj: | Surgical oncology. 30 |
ISSN: | 1879-3320 |
Popis: | Background and aims Previously, colorectal cancer (CRC) metastasis of both liver and lungs was considered disseminated disease, which contraindicated surgical metastasectomies. Increasing evidence from studies on patient series have indicated that survival improved after resecting both liver and lung metastases. However, those results and long-term outcomes remain controversial. We aimed to compare surgical outcomes between patients treated for both liver and lung metastases to the patients who had only isolated liver or lung metastases. Material and methods All patients (n = 105) underwent surgery for CRC metastases between July 2002 and September 2015. Three groups were compared: the sequentially operated group (n = 33 patients) underwent sequential liver and lung resections; the liver group (n = 38 patients) underwent liver resections; and the lung group (n = 34 patients) underwent lung resections. The main endpoints were long-term survival rates. Results The groups were not different in disease-free survival (P = 0.727) or overall survival (P = 0.218). Five-year survival rates were 69.7% in the sequentially operated group, 65.1% in the liver group, and 50.0% in the lung group. Conclusion Long-term outcomes after sequential liver and lung resections of CRC metastases were comparable to outcomes after isolated liver or lung metastasectomies. Therefore, aggressive surgical interventions should be considered for patients with both liver and lung metastases of CRC. |
Databáze: | OpenAIRE |
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