Long-term outcome after sequential liver and lung metastasectomy is comparable to outcome of isolated liver or lung metastasectomy in colorectal carcinoma

Autor: Jari Räsänen, Pauliina Reijonen, Jari Rantonen, Antti Kivelä, Anne Juuti, Helena Isoniemi, Jarmo A. Salo, Arno Nordin
Přispěvatelé: HUS Abdominal Center, Helsinki University Hospital Area, Clinicum, II kirurgian klinikka, Department of Surgery, HUS Heart and Lung Center, III kirurgian klinikka, IV kirurgian klinikka
Rok vydání: 2019
Předmět:
Male
Lung Neoplasms
Time Factors
Lung resections
Colorectal cancer
Liver resections
Gastroenterology
Metastasis
Liver metastases
0302 clinical medicine
Disseminated disease
Pneumonectomy
Isolated liver
Aged
80 and over
Liver Neoplasms
SURGICAL RESECTION
respiratory system
Middle Aged
Word count: 206
Prognosis
3. Good health
Survival Rate
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
SURVIVAL
030211 gastroenterology & hepatology
Female
Metastasectomy
Colorectal Neoplasms
Lung metastases
Adult
medicine.medical_specialty
3122 Cancers
HEPATIC RESECTION
03 medical and health sciences
Colorectal metastases
Internal medicine
medicine
KRAS
MANAGEMENT
Hepatectomy
Humans
CANCER PATIENTS
Aged
Retrospective Studies
Lung
business.industry
PULMONARY METASTASES
MUTATIONS
medicine.disease
3126 Surgery
anesthesiology
intensive care
radiology
respiratory tract diseases
Surgery
business
Follow-Up Studies
Zdroj: Surgical oncology. 30
ISSN: 1879-3320
Popis: Background and aims Previously, colorectal cancer (CRC) metastasis of both liver and lungs was considered disseminated disease, which contraindicated surgical metastasectomies. Increasing evidence from studies on patient series have indicated that survival improved after resecting both liver and lung metastases. However, those results and long-term outcomes remain controversial. We aimed to compare surgical outcomes between patients treated for both liver and lung metastases to the patients who had only isolated liver or lung metastases. Material and methods All patients (n = 105) underwent surgery for CRC metastases between July 2002 and September 2015. Three groups were compared: the sequentially operated group (n = 33 patients) underwent sequential liver and lung resections; the liver group (n = 38 patients) underwent liver resections; and the lung group (n = 34 patients) underwent lung resections. The main endpoints were long-term survival rates. Results The groups were not different in disease-free survival (P = 0.727) or overall survival (P = 0.218). Five-year survival rates were 69.7% in the sequentially operated group, 65.1% in the liver group, and 50.0% in the lung group. Conclusion Long-term outcomes after sequential liver and lung resections of CRC metastases were comparable to outcomes after isolated liver or lung metastasectomies. Therefore, aggressive surgical interventions should be considered for patients with both liver and lung metastases of CRC.
Databáze: OpenAIRE
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