Type 2 Diabetes Is Associated with a Different Pattern of Serum Polyamines: A Case⁻Control Study from the PREDIMED-Plus Trial
| Autor: | Maria Isabel Queipo-Ortuno, Araceli Muñoz-Garach, Fernando Cardona, Antoni Delpino-Rius, María Rosa Bernal-López, Francisco J. Tinahones, Daniel Castellano-Castillo, Iris Samarra, Bruno Ramos-Molina, José Carlos Fernández-García |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
insulin HbA1c endocrine system diseases medicine.medical_treatment polyamines Spermine lcsh:Medicine Type 2 diabetes Article Ornithine decarboxylase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine 030304 developmental biology 0303 health sciences diabetes business.industry Insulin lcsh:R nutritional and metabolic diseases General Medicine Ornithine medicine.disease Endocrinology chemistry 030220 oncology & carcinogenesis Putrescine Metabolic syndrome business case-control |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 8, Iss 1, p 71 (2019) Volume 8 Issue 1 |
| ISSN: | 2077-0383 |
| Popis: | Objective: Polyamines are naturally occurring cationic molecules present in all living cells. Dysregulation of circulating polyamines has been reported in several conditions, but little is known about the levels of serum polyamines in chronic metabolic disorders such as type 2 diabetes (T2D). Therefore, the aim of this study was to evaluate the polyamine-related metabolome in a cohort of metabolic syndrome individuals with and without T2D. Design and methods: This was a nested case–control study within the PREDIMED-Plus trial that included 44 patients with T2D and 70 patients without T2D. We measured serum levels of arginine, ornithine, polyamines, and acetyl polyamines with an ultra-high performance liquid chromatography tandem mass spectrometry platform. Results: Our results showed that serum putrescine, directly generated from ornithine by the catalytic action of the biosynthetic enzyme ornithine decarboxylase, was significantly elevated in patients with T2D compared to those without T2D, and that it significantly correlated with the levels of glycosylated hemoglobin (HbA1c). Correlation analysis revealed a significantly positive association between fasting insulin levels and spermine. Multiple logistic regression analysis (adjusted for age, gender and body weight index) revealed that serum putrescine and spermine levels were associated with a higher risk of T2D. Conclusions: Our study suggests that polyamine metabolism is dysregulated in T2D, and that serum levels of putrescine and spermine are associated with glycemic control and circulating insulin levels, respectively. |
| Databáze: | OpenAIRE |
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