Alteration in Biochemical and Antioxidant Parameters in Patients with Alcoholic Liver Injury
| Autor: | Meena Verma, Haresingh Makwane, Pawan Kumar Kare |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Liver injury
malondialdehyde medicine.medical_specialty Antioxidant business.industry medicine.medical_treatment Clinical Biochemistry lcsh:R lcsh:Medicine General Medicine medicine.disease Gastroenterology superoxide dismutase alcoholic fatty liver disease Internal medicine medicine oxidative stress In patient business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 14, Iss 3, Pp BC08-BC11 (2020) |
| Popis: | Introduction: Alcoholic Liver Disease (ALD) is a result of excessive consumption of alcohol for long duration. Although several biomarkers associated with liver status are known to be influenced by excessive consumption of alcohol, however, the effect of alcohol quantity on biochemical changes and oxidative stress in ALD patients has not explained very well in previous studies. Aim: To find out the alteration in biochemical parameters related to liver functions, antioxidants levels and oxidative stress in ALD patients (both moderate and heavy drinkers). Materials and Methods: In the present study, 260 subjects were recruited from the Department of Medicine, Gastroenterology, SriAurobindo Institute of Medical Sciences (SAIMS) and Hospital, Indore, India and divided in three groups: Group I-(n=75) diagnosed cases of ALD with moderate drinkers Group II-(n=92) diagnosed cases of ALD with heavy drinkers; and Group III included (n=93) normal healthy controls. The levels of serum enzymes such as Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), and γ-Glutamyl Transferase (GGT), total protein, total bilirubin and lipid parameters such as total cholesterol, triglyceride, High Density Cholesterol (HDL) and Low Density Cholesterol (LDL) were measured by fully automated chemistry analyser. The levels of antioxidants such as Superoxide Dismutase (SOD), Catalase (CAT) and oxidative stress marker such as Malondialdehyde (MDA) was estimated by spectrophotometric method. p |
| Databáze: | OpenAIRE |
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