Penetration of amoxicillin into cerebrospinal fluid
| Autor: | Mohamed W. Yassin, David C. Edman, Walter F. Miner, Isis A. Mikhail, Nabil I. Girgis, Larry J. Strausbaugh |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Oral dose
Adult Male Time Factors Adolescent Sodium chemistry.chemical_element Capsules Tuberculous meningitis Meningeal inflammation Cerebrospinal fluid Ampicillin Medicine Humans Pharmacology (medical) Child Pharmacology business.industry Amoxicillin Penetration (firestop) medicine.disease Pharmacology and Therapeutics Infectious Diseases chemistry Anesthesia Tuberculosis Meningeal Injections Intravenous Drug Evaluation Female business medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 14(6) |
| ISSN: | 0066-4804 |
| Popis: | The penetration of amoxicillin into cerebrospinal fluid (CFS) in the presence of meningeal inflammation was evaluated in patients with tuberculous meningitis. Serum and CSF concentrations of amoxicillin were measured at 2 h in nine patients who received a 1-g oral dose and at 1.5 and 4 h in ten patients who received a 2-g intravenous injection of sodium amoxicillin. After the oral dose, CSF concentrations ranged from 0.1 to 1.5 μg/ml. After the intravenous injection, CSF concentrations ranged from 2.9 to 40.0 μg/ml at 1.5 h and from 2.6 to 27.0 μg/ml at 4 h. These data on penetration suggest that parenterally administered sodium amoxicillin may be of value in the therapy of acute bacterial meningitis. |
| Databáze: | OpenAIRE |
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