Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia
| Autor: | David G. Gadian, Faraneh Vargha-Khadem, Kate E. Watkins, Emma Belton, C. H. Salmond |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
Adolescent Apraxias Planum temporale Caudate nucleus Inferior frontal gyrus Grey matter Functional Laterality Speech Disorders Image Processing Computer-Assisted medicine Humans Point Mutation Radiology Nuclear Medicine and imaging Child Research Articles Radiological and Ultrasound Technology medicine.diagnostic_test Forkhead Transcription Factors Magnetic resonance imaging FOXP2 Voxel-based morphometry Anatomy KE family Magnetic Resonance Imaging medicine.anatomical_structure Neurology Female Neurology (clinical) Caudate Nucleus Psychology Transcription Factors |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| Popis: | The KE family is a large three‐generational pedigree in which half of the members suffer from a verbal and orofacial dyspraxia in association with a point mutation in the FOXP2 gene. This report extends previous voxel‐based morphometric analyses of magnetic resonance imaging (MRI) scans (Watkins et al. [2002] Brain 125:465–478) using a bilateral conjunction analysis. This searches specifically for areas of grey matter density that differ bilaterally in the affected members compared with both matched controls and the unaffected family members. 3‐D T1‐weighted MRI datasets of 17 family members (10 affected, 7 unaffected) and matched controls were compared. The most significant findings were reduced grey matter density bilaterally in the caudate nucleus, the cerebellum, and the left and right inferior frontal gyrus in the affected members. In addition, increased grey matter density was found bilaterally in the planum temporale. These results confirm that a point mutation in FOXP2 is associated with several bilateral grey matter abnormalities in both motor and language related regions. The results also demonstrate the advantages of using a conjunction analysis when bilateral abnormalities are suspected. Hum. Brain Mapping 18:194–200, 2003. © 2003 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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