Construction of Bispirooxindole Heterocycles via Palladium-Catalyzed Ring-Opening Formal [3 + 2]-Cycloaddition of Spirovinylcyclopropyl Oxindole and 3-Oxindole Derivatives

Autor:	Hua Yang, Wen-Qiang Chen, Wei Su, Zhi-Jin Luo, Xiu-Liang Cheng, Zhi-Xiong Deng, Yuchun Li, Jun-An Xiao
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry Ring (chemistry) 01 natural sciences Combinatorial chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound Yield (chemistry) Oxindole Palladium
Zdroj:	The Journal of Organic Chemistry. 84:2297-2306
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.8b02889
Popis:	A palladium-catalyzed ring-opening oxo-formal [3 + 2]-cycloaddition reaction of novel donor-acceptor spirovinylcyclopropyl oxindole with 3-oxindole is described. The developed protocol provides facile access to oxo-bispirooxindole derivatives in good yields (up to 82% yield) with excellent diastereoselectivities (up to 20:1 dr).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c5f70d04fd399cb560eb1c9d310e81 https://doi.org/10.1021/acs.joc.8b02889 Zobrazit plný text záznamu