Effect of donor and recipient variables on the long-term live-donor renal allograft survival in children
| Autor: | Mohamed A. Fouda, Ehab W. Wafa, Nabil M. Hassan, Ahmed Akl, Ahmed A. Shokeir, Mohamed A. Ghoneim, Kalid El Dahshan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Live donor renal allograft Live donor Urology ATN acute tubular necrosis Kidney transplantation HLA - Human leukocyte antigen BWR body weight ratio NAPRTCS North American Pediatric Renal Transplant Cooperative Study Internal medicine Medicine End-stage kidney disease Children Acute tubular necrosis Outcome UNOS United Network for Organ Sharing business.industry HLA human leukocyte antigen medicine.disease ESKD end-stage kidney disease surgical procedures operative DR donor/recipient Graft survival business Renal Transplantation Original Article |
| Zdroj: | Arab Journal of Urology |
| ISSN: | 2090-5998 2090-598X |
| Popis: | Objective We aimed to analyse donor and recipient predictors of graft survival in children who received live-donor renal grafts. Patients and methods The study comprised 273 children who received live-donor renal transplants at our center between March 1976 and October 2010. The follow-up ranged from 6 months to 25 years. Donor variables included donor age, gender, donor/recipient body weight ratio (DR BWR), ABO blood groups, human leukocyte antigen, and DR mismatching. Donor-specific problems, e.g., ischemia time during surgery and number of renal arteries, were included. Recipient variables included recipient age, sex, original kidney disease, ischemia time, acute tubular necrosis (ATN) after transplantation, immunosuppression, number of acute rejection episodes, re-transplantation, and development of hypertension. Results Independent variables with a sustained effect on the 5- and 10-year graft survival on multivariate analysis were: ATN after transplant, number of acute rejections, hypertension, and DR BWR. At the last follow-up, 185 patients (67.8%) had a functioning graft, while 82 (30.0%) had graft failure. Only six patients (0.02%) were lost to follow-up. Conclusion Donor and recipient variables that affect short- and long-term graft survival in children with a live-donor renal allograft are DR BWR, number of acute rejections, ATN and hypertension after transplant. Considering these variables provides a better outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|