The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis
| Autor: | Yuquan Xie, Haozhu Chen, Ruizhen Chen, Xu-Jie Liu, Yingzhen Yang, Yunzeng Zou, Yeqing Xie, Xian Zhang, Junbo Ge, Yong Yu, Ping Chen |
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| Jazyk: | angličtina |
| Předmět: |
Viral Myocarditis
Myocarditis Coxsackievirus Infections chemical and pharmacologic phenomena T-Lymphocytes Regulatory Neutralization Pathogenesis Mice Virology Viral myocarditis medicine Animals Humans Gene Th17 cell Mice Inbred BALB C biology hemic and immune systems medicine.disease Isotype Treg cell Enterovirus B Human Disease Models Animal Perforin Viral replication Immunology biology.protein Coxsackievirus B Cytokines Th17 Cells HeLa Cells |
| Zdroj: | Virology. (1):78-84 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2011.09.006 |
| Popis: | IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC. |
| Databáze: | OpenAIRE |
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