Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease
| Autor: | Philip Chen, Paul A. Bates, Priscilla Le Poidevin, Martin F. Lavin |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Chromosome Aberrations
DNA synthesis Somatic cell Lymphoblast DNA replication DNA Fibroblasts Biology Flow Cytometry Toxicology Radiation Tolerance DNA Synthesis Inhibition Ionizing radiation Alzheimer Disease Cell culture Immunology Genetics Cancer research Humans Radiosensitivity Down Syndrome Molecular Biology Cell Line Transformed |
| Zdroj: | Mutation Research/DNA Repair. 218:41-47 |
| ISSN: | 0921-8777 |
| DOI: | 10.1016/0921-8777(89)90045-1 |
| Popis: | Inhibition of DNA synthesis was studied in gamma-irradiated lymphoblastoid cells from patients with Alzheimer's disease and Down's syndrome. A normal biphasic pattern of inhibition was observed over a dose range of 0-4 krad of gamma-rays in all of the cell lines. 3 out of 4 Down's and all the Alzheimer's cell lines were shown to be hypersensitive to ionizing radiation based on induced chromosomal aberrations. Increased G2 phase delay, comparable to that occurring in ataxia-telangiectasia cells, was observed for some of the cell lines, after exposure to gamma-rays. Contrary to other data in the literature these results demonstrate that radioresistant DNA synthesis is not an intrinsic feature of all disorders characterized by radiosensitivity. |
| Databáze: | OpenAIRE |
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