Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles

Autor: Felipe Augusto Pinto-Vidal, Raquel Fernanda Salla, Lilian Franco-Belussi, Cristiane R Oliveira, Monica Jones-Costa, Iolanda Cristina Silveira Duarte, Fábio Camargo Abdalla, Classius de Oliveira, Elaine C.M. Silva-Zacarin, Bruno Fernando Santos de Souza
Přispěvatelé: Universidade Federal de São Carlos (UFSCar), Universidade Estadual Paulista (Unesp), Universidade Federal de Mato Grosso do Sul (UFMS), Masaryk University
Rok vydání: 2021
Předmět:
Sodium dodecylbenzene sulfonate
medicine.medical_specialty
Environmental Engineering
Surfactants
Health
Toxicology and Mutagenesis
0208 environmental biotechnology
Hemosiderin
02 engineering and technology
010501 environmental sciences
01 natural sciences
Surface-Active Agents
Bullfrog
Detoxification
Internal medicine
medicine
Animals
Environmental Chemistry
0105 earth and related environmental sciences
Rana catesbeiana
Catabolism
Chemistry
Morphometry
Immune cells
Public Health
Environmental and Occupational Health
General Medicine
General Chemistry
Metabolism
Pollution
020801 environmental engineering
medicine.anatomical_structure
Endocrinology
Alkanesulfonic Acids
Vacuolization
Larva
Hepatocyte
Hepatocytes
Chemical and Drug Induced Liver Injury
Hepatic melanomacrophages
Brazil
Homeostasis
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2020.129014
Popis: Made available in DSpace on 2021-06-25T10:48:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) British and Foreign School Society The liver of anurans play an important role in metabolism, including detoxification, the biotransformation of molecules, and the storage of metabolites. Surfactants are part of domestic and industrial effluents. The effects of linear alkylbenzene sulfonate (LAS) on anuran liver remain unknown, however, some studies have evaluated the effects of LAS on the skin, gills, heart, testes, and liver of fishes. Here, we tested the hypothesis that LAS is hepatotoxic, promoting morphometric alterations in hepatocytes along with inflammation in the tissue, altering hepatic catabolism. We evaluated the effects of a LAS concentration that is considered environmentally safe in Brazilian inland waters on the liver of Lithobates catesbeianus tadpoles, including studies on morphology, morphometry, immunology, and metabolism. LAS exposure promoted enlargement of liver sinusoids and vacuolization of hepatocytes. Exposure to LAS also increased the area of mast cells and melanomacrophages (MMs). Additionally, LAS exposure increased hemosiderin inside MMs, suggesting alterations in the catabolism and storage of iron. Hepatocyte size increased after exposure to LAS, suggesting cytotoxic effects. Integrative analyses (i.e., morphometric, metabolic, and immunological) demonstrated hepatotoxic effects of LAS. These types of studies are key to understanding the negative effects of these substances on tadpole health, as these liver alterations impair anuran homeostasis. Laboratório de Fisiologia da Conservação (LAFISC) Universidade Federal de São Carlos (UFSCar) Departamento de Biologia Universidade Estadual Paulista (UNESP), São José do Rio Preto Laboratório de Patologia Experimental (LAPEx) Instituto de Biociências (INBIO) Universidade Federal de Mato Grosso do Sul UFMS Laboratório de Ecotoxicologia e Biomarcadores Em Animais (LEBA) Universidade Federal de São Carlos, Sorocaba Laboratório de Biologia Estrutural e Funcional Universidade Federal de São Carlos, Sorocaba Laboratório de Microbiologia Ambiental (LAMA) Universidade Federal de São Carlos, Sorocaba RECETOX Faculty of Science Masaryk University, Kamenice 753/5, Pavilion A29 Departamento de Biologia Universidade Estadual Paulista (UNESP), São José do Rio Preto CNPq: #573921/2008–3 FAPESP: 08/57712–4 FAPESP: 2014/00946–4 British and Foreign School Society: 304552/2019–4 CNPq: 304552/2019–4 CNPq: 573921/2008–3
Databáze: OpenAIRE
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