Clinical implications of fibroblast activation protein-α in non-small cell lung cancer after curative resection: a new predictor for prognosis
| Autor: | Ren He, Yida Liao, Weidong Liu, Yang Ni, Jiajun Du |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Lung Neoplasms Stromal cell Neutrophils Inflammation Adenocarcinoma Immunoenzyme Techniques Fibroblast activation protein alpha Carcinoma Non-Small-Cell Lung Internal medicine Endopeptidases Biomarkers Tumor medicine Carcinoma Humans Lymphocytes Lung cancer neoplasms Survival rate Aged Neoplasm Staging Hematology business.industry Serine Endopeptidases Membrane Proteins Cancer General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Survival Rate Gelatinases Lymphatic Metastasis Carcinoma Squamous Cell Disease Progression Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 139:1523-1528 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | Fibroblast activation protein-α (FAP-α), which is a serine protease specially expressed on the surface of the cancer stromal cells, plays an important role in the progression and prognosis in diverse malignancies. However, the role of FAP-α in non-small cell lung cancer (NSCLC) is still unknown.We enrolled 59 NSCLC patients who received complete resection. Sections of paraffin-embedded primary NSCLC specimens of all the patients were stained with antibody directed against FAP-α. Overall, percentage (Grade 0-3) and intensity (0-3+) of stromal FAP-α staining of the tumor were assessed.FAP-α was detected in76 % of the specimens examined, and its high expression seemed to be correlated with poor tumor differentiation (P = 0.06). Furthermore, both increased FAP-α staining percentage and intensity were associated with worse overall survival of the patients (percentage, P = 0.0087; intensity, P = 0.05). Higher FAP-α staining percentage was observed in those patients with increased peripheral neutrophil and lymphocyte count ratio (P = 0.034).FAP-α is highly expressed in cancer stroma and also a predictor of poor survival of NSCLC patients. Elevated FAP-α expression may be associated with inflammation and suppressed lymphocyte-dependent immune response, which then result in the tumor progression. Therefore, FAP-α plays an important role in the progression of NSCLC, and its high expression is a predictor of poor survival. Targeting FAP-α may be a novel strategy for NSCLC therapy. |
| Databáze: | OpenAIRE |
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