Use of bremsstrahlung radiation to identify hidden weak β− sources: feasibility and possible use in radio-guided surgery
Autor: | Francesco Collamati, R. Mirabelli, M. Toppi, A. Russomando, D. Carlotti, M. Marafini, Carlo Mancini-Terracciano, L. Recchia, V. Bocci, R. Faccini, G. Traini, P. Fresch, Francesco Iacoangeli, E. Solfaroli Camillocci |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Physics
medicine.medical_specialty Intra-operative probes X-ray detectors Photon Physics - Instrumentation and Detectors Detector Bremsstrahlung FOS: Physical sciences Instrumentation and Detectors (physics.ins-det) Radiation Electromagnetic radiation 030218 nuclear medicine & medical imaging Surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Secondary emission Beta particle medicine Quantum efficiency Instrumentation Mathematical Physics |
Popis: | The recent interest in beta- radionuclides for radio-guided surgery derives from the feature of the beta radiation to release energy in few millimeters of tissue. Such feature can be used to locate residual tumors with a probe located in its immediate vicinity, determining the resection margins with an accuracy of millimeters. The drawback of this technique is that it does not allow to identify tumors hidden in more than few mm of tissue. Conversely, the bremsstrahlung X-rays emitted by the interaction of the beta- radiation with the nuclei of the tissue are relatively penetrating. To complement the beta- probes, we have therefore developed a detector based on cadmium telluride, an X-ray detector with a high quantum efficiency working at room temperature. We measured the secondary emission of bremsstrahlung photons in a target of Polymethylmethacrylate (PMMA) with a density similar to living tissue. The results show that this device allows to detect a 1 ml residual or lymph-node with an activity of 1 kBq hidden under a layer of 10 mm of PMMA with a 3:1 signal to noise, i.e. with a five sigma discrimination in less than 5 s. |
Databáze: | OpenAIRE |
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