Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins
| Autor: | Rui Wang, Rui San Zhang, Min Chang, Yifan Han, Sheng Quan Hu, Chung Lit Choi, Peng Yali, Pei Wang, Ming Yin, Ren Wen Han |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Scopolamine Morris water navigation task Mice Inbred Strains Water maze Cholinergic Antagonists Mice In vivo Reaction Time medicine Animals Maze Learning Molecular Biology Recognition memory Analysis of Variance Memory Disorders Dose-Response Relationship Drug Learning Disabilities General Neuroscience Retention Psychology Recognition Psychology Cognition Disease Models Animal Tacrine Cholinesterase Inhibitors Neurology (clinical) Psychology Neuroscience Cognitive load Developmental Biology Cognitive psychology Reverse learning medicine.drug |
| Zdroj: | Brain Research. 1470:59-68 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2012.06.015 |
| Popis: | Our previous reports indicated that bis(propyl)-cognitin (B3C) and bis(heptyl)-cognitin (B7C), as novel dimers derived from tacrine, may be potential multifunctional drugs for treating Alzheimer's disease. There is little knowledge on the cognitive function of B3C while B7C appeared to reverse learning and memory impairments. In this study, for the first time, we evaluated the anti-amnesic effects of B3C and B7C on learning and memory deficits induced by scopolamine using both Morris water maze and novel object recognition tasks in mice. Under the same experimental condition, the anti-amnesic effect of tacrine was also compared. Briefly, in both tasks, scopolamine (0.1-0.6 mg/kg, ip) dose-dependently impaired learning and memory functions. B3C (1.5-2.5 mu mol/kg), B7C (0.4-0.6 mu mol/kg) or tacrine (8-12 mu mol/kg), each administered ip, dose-dependently mitigated scopolamine-induced learning and memory impairments in both tasks. Our present results show, for the first time, that B3C and B7C reverse cognitive impairment resulted from scopolamine in both water maze and object recognition tasks; and under the same condition, the relative potency of B3C and B7C to improve cognitive capacity was 5-20 folds over that of tacrine. These novel in vivo findings further demonstrate that both B3C and B7C may potentially be developed as Alzheimer's therapeutic drugs for different severities of neurodegenerations. (C) 2012 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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