Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis

Autor:	Shu-Ling, Hsieh, Jia-Huei, Li, Cheng-Di, Dong, Chiu-Wen, Chen, Chih-Chung, Wu
Rok vydání:	2021
Předmět:	carnosine autophagy angiogenesis Cancer Research cell proliferation Oncology apoptosis necroptosis Articles
Zdroj:	Oncology Letters
ISSN:	1792-1082 1792-1074
DOI:	10.3892/ol.2021.13162
Popis:	Carnosine (β-alanyl-L-histidine) is found in beef and fish. The present study aimed to investigate the effects of carnosine on the cell proliferation of human colorectal cancer cells. After human colorectal cancer HCT-116 cells were treated carnosine for 72 or 96 h, the cell proliferation, apoptosis, autophagy, necroptosis, angiogenesis and the expression of related regulatory molecules were detected using MTT assays, fluorescence image analysis and RT-qPCR in this study. Treatment of HCT-116 cells with 5, 10 or 15 mM carnosine for 72 or 96 h significantly decreased cell viability (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b5ace2365defcdab22f32088a57607 https://doi.org/10.3892/ol.2021.13162 Zobrazit plný text záznamu