Accuracy of Xpert MTB/RIF assay for the diagnosis of tuberculous pleural effusion

Autor: Yi‐Ran Qiu, Yu‐Yan Chen, Xin‐Ran Wu, Ya‐Ping Li, Xun‐Jie Cao, Zi‐Yuan Yu, Min Lin, Qiu‐Yin Li, Ji‐Chun Chen, Xin Yin, Shu‐Chang Weng, Xu‐Guang Guo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Tuberculosis poses a severe threat to human health. At present, compared with the traditional diagnostic methods for tuberculosis pleural effusion, such as Löwenstein–Jensen culture, pleural biopsy, and Ziehl–Neelsen smear microscopy, Xpert MTB/RIF was regarded as an emerging technology for its efficiency. The Xpert MTB/RIF accuracy for tuberculous pleural effusion diagnosis was evaluated in this systematic study. Materials and methods We searched the relevant literature published before January 2021 in PubMed, Cochrane, EMBASE, and Web of Science databases. Utilizing Review Manager 5.3 software, the quality of the included literature was evaluated based on the Quality Assessment of Diagnostic Accuracy Studies criteria. Sensitivity, specificity, and the summary receiver operating characteristic curves were plotted and analyzed with Metadisc 1.40 software. We used Stata 12.0 software to evaluate the publication bias of this study. Results Eighteen articles were identified in total. The sensitivity of Xpert MTB/RIF in the pleural effusion was 0.24, and specificity was 1.00, respectively. The area under the summary receiver operating characteristic curve was 0.9737, which indicated that the overall accuracy of the Xpert MTB/RIF was high. In addition, based on the Deeks funnel plot, no publication bias of the study was found. Conclusion Xpert MTB/RIF is a rapid method with high specificity but relatively low sensitivity for detecting Mycobacterium tuberculosis in pleural effusion. Its less sensitivity made it difficult to be used clinically, but the high specificity suggests that it can be used as a specific diagnostic method for tuberculous pleural effusion.
SROC curve was plotted, and the following parameters were obtained: AUC of 0.9737 and Q of 0.9260 (SE = 0.0512). The SROC turn was near the top left corner, and the AUC was close to 1, which suggested that Xpert MTB/RIF had a comparatively overall high diagnostic accuracy for pleural effusion.
Databáze: OpenAIRE
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