Association of paraoxonase (PON1) polymorphisms and activity with colorectal cancer predisposition

Autor:	Ilhan Yaylim, Yaman Tekant, Hayriye Ergen, Tugrul Demirel, Mustafa Kayıhan Günay, Turgay Isbir
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Antioxidant antioxidant biology business.industry Colorectal cancer medicine.medical_treatment lcsh:Biotechnology Paraoxonase paraoxonase 1 colorectal cancer medicine.disease PON1 Enzyme assay polymorphism predisposition lcsh:TP248.13-248.65 Cancer research biology.protein medicine business Biotechnology
Zdroj:	Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 232-238 (2021)
ISSN:	1314-3530 1310-2818
Popis:	Paraoxonase 1 (PON1) is a well recognised member of human endogeneous free radical scavenging systems and its polymorphism and enzyme activity are attributed to various different cancer formations. We aimed to study the Paraoxonase 1 (PON1) polymorphism and enzyme activity in colorectal cancer patients. Peripheral blood samples for DNA extraction were collected from 54 colorectal cancer patients and 85 healthy individuals. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were used for determination of the PON1192 polymorphism. The frequency of AA genotype was greater than BB and AB genotypes in all groups (n:65 with 46.8%; n:15 with 10.8% and n:59 with 42.4%, respectively). In both tumor groups, PON activities were significantly lower than the control group (p
Databáze:	OpenAIRE
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