Phocine Distemper Virus in Seals, East Coast, United States, 2006
| Autor: | Ole Nielsen, S. Louise Cosby, J.A. Philip Earle, Mary M. Melia, Nadine V. Doherty |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Epidemiology Phocine distemper virus viruses Molecular Sequence Data lcsh:Medicine Phoca Biology medicine.disease_cause phylogeny epizootic Virus lcsh:Infectious and parasitic diseases Viral Proteins Chlorocebus aethiops medicine Animals lcsh:RC109-216 Amino Acid Sequence Distemper Maine Gene Vero Cells Distemper Virus Phocine East coast Mutation persistent infection Research lcsh:R Sequence Analysis DNA genomic sequence biology.organism_classification mutations central nervous system Virology United States Infectious Diseases Massachusetts Phosphoprotein Vero cell RNA Viral Sequence Alignment morbilliviruses |
| Zdroj: | Emerging Infectious Diseases, Vol 17, Iss 2, Pp 215-220 (2011) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Phocine Distemper Virus in Seals In 2006 and 2007, elevated numbers of deaths among seals, constituting an unusual mortality event, occurred off the coasts of Maine and Massachusetts, United States. We isolated a virus from seal tissue and confirmed it as phocine distemper virus (PDV). We compared the viral hemagglutinin, phosphoprotein, and fusion (F) and matrix (M) protein gene sequences with those of viruses from the 1988 and 2002 PDV epizootics. The virus showed highest similarity with a PDV 1988 Netherlands virus, which raises the possibility that the 2006 isolate from the United States might have emerged independently from 2002 PDVs and that multiple lineages of PDV might be circulating among enzootically infected North American seals. Evidence from comparison of sequences derived from different tissues suggested that mutations in the F and M genes occur in brain tissue that are not present in lung, liver, or blood, which suggests virus persistence in the central nervous system. |
| Databáze: | OpenAIRE |
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