IV crystalloid fluid for acute alcoholic intoxication prolongs ED length of stay

Autor: Takashi Shiga, Yoshiyuki Nakashima, Yuiko Hoshina, Yosuke Homma, Hiraku Funakoshi, Michiko Mizobe, Jin Takahashi, Osamu Takahashi, Tetsuya Inoue, Kenji Numata
Rok vydání: 2017
Předmět:
Adult
Male
030508 substance abuse
03 medical and health sciences
Young Adult
0302 clinical medicine
Sobriety
Alcohol intoxication
Cox proportional hazards regression
Medicine
Humans
Infusions
Intravenous
reproductive and urinary physiology
Retrospective Studies
Ethanol
business.industry
Confounding
Significant difference
030208 emergency & critical care medicine
Retrospective cohort study
General Medicine
Crystalloid Solutions
Length of Stay
Acute alcoholic intoxication
medicine.disease
female genital diseases and pregnancy complications
Gastrointestinal Absorption
Anesthesia
Baseline characteristics
Rehydration Solutions
Emergency Medicine
Blood Alcohol Content
Female
Isotonic Solutions
0305 other medical science
business
Emergency Service
Hospital
Alcoholic Intoxication
hormones
hormone substitutes
and hormone antagonists
Zdroj: The American journal of emergency medicine. 36(4)
ISSN: 1532-8171
Popis: Objectives Acute alcohol intoxication is often treated in emergency departments by intravenous crystalloid fluid (IVF), but it is not clear that this shortens the time to achieving sobriety. The study aim was to investigate the association of IVF infusion and length of stay in the ED. Methods This single-center retrospective cohort study was conducted in Japan and included patients aged ≥ 20 years of age and treated for acute alcohol intoxication without or with IVF. The primary outcome was the length of the ED stay and the treatments were compared by time-to-event analysis. Results A total of 106 patients, 42 treated without IVF and 64 with IVF. The baseline characteristics of the two groups were similar. Kaplan–Meier analysis and the generalized Wilcoxon test found no significant difference between the two treatments in the time to ED discharge. The median time was 189 (IQR 160–230) minutes without IVF and 254.5 (203–267 minutes with IVF; p = 0.052). A Cox proportional hazards regression model adjusted for potential confounding variables found that patients treated with IVF were less likely to be discharged earlier than those treated without IVF (HR 0.54, 95% CI: 0.35–0.84, p = 0.006). Conclusions IVF for treatment of acute alcoholic intoxication prolonged ED length of stay even after adjustment for potential confounders. Patients given IVF for acute alcohol intoxication should be selected with care.
Databáze: OpenAIRE
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