Effects of Glycine on Collagen, PDGF, and EGF Expression in Model of Oral Mucositis
| Autor: | Maria Teresa de Seixas Alves, Eliana Maria Monteiro Caran, Nilza Nelly Fontana Lopes, Odara Maria de Sousa Sá |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Anti-Inflammatory Agents Hamster lcsh:TX341-641 Pharmacology Article Collagen Type I 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Epidermal growth factor Cricetinae Mucositis Animals Medicine Platelet Platelet-Derived Growth Factor HEPES Stomatitis Wound Healing Nutrition and Dietetics Epidermal Growth Factor biology business.industry Mouth Mucosa Cancer medicine.disease proteins 030104 developmental biology chemistry 030220 oncology & carcinogenesis Dietary Supplements Glycine biology.protein Female intercellular signaling peptides business lcsh:Nutrition. Foods and food supply Platelet-derived growth factor receptor oral mucositis glycine Food Science |
| Zdroj: | Nutrients Volume 10 Issue 10 Nutrients, Vol 10, Iss 10, p 1485 (2018) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10101485 |
| Popis: | Oral mucositis is frequently a toxic effect of chemotherapeutic and/or radiotherapeutic treatment, resulting from complex multifaceted biological events involving DNA damage. The clinical manifestations have a negative impact on the life quality of cancer patients. Preventive measures and curative treatment of mucositis are still not well established. The glycine has anti-inflammatory, immunomodulatory, and cytoprotective actions, being a potential therapeutic in mucositis. The objective was to evaluate the effects of glycine on the expression of collagen and growth factors, platelet and epidermal in a hamster model oral mucositis. The mucositis was induced by the protocol of Sonis. There were 40 hamsters used, divided into two groups: Group I-control Group II-supplemented with 5% intraperitoneal glycine, 2.0 mg/g diluted in hepes. Histopathological sections were used to perform the immune-histochemical method, the evaluation of collagen expression, and the growth factors: Epidermal growth factor (EGF) and platelet (PDGF). It was observed that the group supplemented with glycine experienced higher amounts of collagen expression and predominance type of collagen I. The glycine group presented lower immunoexpression of the growth factors, EGF and PDGF. The group supplemented with glycine showed a marked healing process of the oral mucosite, demonstrated by the predominance of collagen type I and reduction of growth factors, EGF and PDGF. |
| Databáze: | OpenAIRE |
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