Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence

Autor: Jurandir Fernando Comar, Luis F. Ponsoni, Luiz A. F. Lopes, Pablinny Moreira Galdino de Carvalho, Roberto Kenji Nakamura Cuman, Gustavo R Villas-Boas, Mila S Cunha, Roseli Boerngen de Lacerda, Saulo Euclides Silva-Filho, Silvia Aparecida Oesterreich, Bruno H. da S. Ramos, Raphael Contelli Klein, Adryano Augustto Valladao de Carvalho, Mary Hellen Fabres Klein, Katyuscya V. Leão, Lais da S. Leite, Dayane G. de L. Ribas, Francielli Maria de Souza Silva-Comar, Manoel F. de Magalhães-Filho, Ana Paula Stefanello da Silveira, Vanessa C Rescia, Matheus Da Silva Tavares-Henriques, Stefânia Neiva Lavorato, Marina Meirelles Paes, Luana do A. Brasileiro, Jonatas G. da Silva, Luiz Gustavo Rodrigues Oliveira, William Rodrigues de Freitas, Jussileide N. dos Santos, Cristiane K. C. Fernandes
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 148, p 148 (2021)
ISSN: 1424-8247
Popis: Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems, mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT receptors are currently promising targets for discovering new drugs for treating disorders ranging from migraine to neuropsychiatric upsets, such as anxiety and depression. It is well described in the current literature that the brain expresses seven types of 5-HT receptors comprising eighteen distinct subtypes. In this article, we comprehensively reviewed 5-HT1-7 receptors. Of the eighteen 5-HT receptors known today, thirteen are G protein-coupled receptors (GPCRs) and represent targets for approximately 40% of drugs used in humans. Signaling pathways related to these receptors play a crucial role in neurodevelopment and can be modulated to develop effective therapies to treat anxiety and depression. This review presents the experimental evidence of the modulation of the “serotonergic receptosome” in the treatment of anxiety and depression, as well as demonstrating state-of-the-art research related to phytochemicals and these disorders. In addition, detailed aspects of the pharmacological mechanism of action of all currently known 5-HT receptor families were reviewed. From this review, it will be possible to direct the rational design of drugs towards new therapies that involve signaling via 5-HT receptors.
Databáze: OpenAIRE
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