TMC-49A, a Novel Transcriptional Up-Regulator of Low Density Lipoprotein Receptor, Produced by Streptomyces sp. AS1345
| Autor: | Yutaka Koguchi, Yasuyuki Asai, Noriyuki Yanaka, Tetsuo Ohnuki, Maki Nishio, Shin-Ichi Suzuki, Kenji Omori, Saburo Komatsubara |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Reporter gene Transcription Genetic biology Streptomycetaceae biology.organism_classification Urethane Streptomyces Up-Regulation chemistry.chemical_compound Receptors LDL Biosynthesis chemistry Biochemistry Low-density lipoprotein Fermentation Drug Discovery LDL receptor Tumor Cells Cultured Humans Carbamates Actinomycetales Receptor |
| Zdroj: | The Journal of Antibiotics. 51:107-111 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phenethylcarbamate by spectroscopic analyses. This compound enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Taxonomy of the producing strain is also described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|