Autoimmune hemolytic anemia associated with babesiosis
Autor: | John C. Nelson, Delong Liu, Roshni Narurkar, Aleksandra Mamorska-Dyga |
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Rok vydání: | 2017 |
Předmět: |
Anemia
medicine.medical_treatment Clinical Biochemistry Splenectomy Babesia Case Report 030204 cardiovascular system & hematology Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Medicine 030212 general & internal medicine Babesia infection Atovaquone business.industry Autoimmune Hemolytic Anemia lcsh:RM1-950 Biochemistry (medical) Babesiosis Paroxysmal Nocturnal Hemoglobinuria medicine.disease Blood Parasite lcsh:Therapeutics. Pharmacology Immunology Molecular Medicine Autoimmune hemolytic anemia business Hyponatremia |
Zdroj: | Biomarker Research, Vol 5, Iss 1, Pp 1-4 (2017) Biomarker Research |
ISSN: | 2050-7771 |
Popis: | Background Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is known to be caused by parasitic and viral infections but has not been well characterized. Case presentation We describe two cases diagnosed with babesiosis triggering severe AIHA. One case had history of splenectomy, and the other was an elderly patient. Older, immunocompromised and asplenic patients may be particularly at risk for post-babesiosis AIHA (PB-AIHA). Conclusions The pathogenesis for conventional AIHA and PB-AIHA appears to be different, since splenectomy is a treatment for conventional AIHA, whereas PB-AIHA is seen more often in asplenic patients. Further investigation into this intriguing mechanism of host immune response to babesiosis may help to elucidate the overall mechanism of infection- triggered AIHA. |
Databáze: | OpenAIRE |
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