Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus Emericella sp. XL029
| Autor: | Ting Zhao, Deng-Feng Yang, Xia Wu, Xue-Jiao Pang, Hai-Li Qin, Qiong-Yin Zhang, Xiao-Long Yang, Xin-Yu Long, Lu-Lin Xu |
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| Rok vydání: | 2017 |
| Předmět: |
Antifungal Agents
Panax notoginseng Plant Science Microbial Sensitivity Tests Alkylation 01 natural sciences Biochemistry Plant use of endophytic fungi in defense Analytical Chemistry Microbiology Rhizoctonia Rhizoctonia solani chemistry.chemical_compound Fusarium Furan Fusarium oxysporum Furans Emericella biology Bacteria Molecular Structure 010405 organic chemistry Organic Chemistry biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Antibacterial activity |
| DOI: | 10.6084/m9.figshare.5422507.v1 |
| Popis: | Two new alkylated furan derivatives, 5-(undeca-3′,5′,7′-trien-1′-yl)furan-2-ol (1) and 5-(undeca-3′,5′,7′-trien-1′-yl)furan-2-carbonate (2), were isolated from the crude extract of the plant endophytic fungus Emericella sp. XL029 associated with the leaves of Panax notoginseng. The anti-agricultural pathogenic fungal assay indicated that compound 1 displayed significant activity against all tested fungi with minimum inhibitory concentrations (MIC) values from 25 to 3.1 μg/mL, while compound 2 displayed activity against all tested fungi except for Rhizoctonia solani and Fusarium oxysporum with MIC values from 50 to 12.5 μg/mL. Furthermore, compounds 1–2 also exhibited significant inhibitory activity against eight of thirteen tested bacteria with MIC values ranging from 50 to 6.3 μg/mL. |
| Databáze: | OpenAIRE |
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