Eglerisine, a Novel Sesquiterpenoid Tropolone from Dulacia egleri with Antiproliferative Effect against an Acute Myeloid Leukemia Lineage
| Autor: | L. F. Ferreira, Carlos Henrique Corrêa dos Santos, Paulo Teixeira de Sousa, Tereza A. N. Ribeiro, Heron Fernandes Vieira Torquato, Leice M. R. de Novais, Marcos J. Jacinto, Edgar J. Paredes-Gamero, Mario Geraldo de Carvalho, Virgínia C. P. Silva |
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| Rok vydání: | 2019 |
| Předmět: |
Magnetic Resonance Spectroscopy
Myeloid Cell cycle checkpoint Pharmaceutical Science 01 natural sciences Analytical Chemistry Histones chemistry.chemical_compound Cell Line Tumor Drug Discovery medicine Humans Cell Proliferation Pharmacology Molecular Structure Plant Extracts 010405 organic chemistry Chemistry Cell Cycle Organic Chemistry Myeloid leukemia Cell cycle medicine.disease Antineoplastic Agents Phytogenic Molecular biology Tropolone 0104 chemical sciences Leukemia Myeloid Acute 010404 medicinal & biomolecular chemistry Leukemia medicine.anatomical_structure Complementary and alternative medicine Cell culture Apoptosis Molecular Medicine Olacaceae Sesquiterpenes |
| Zdroj: | Planta Medica. 86:55-60 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/a-1021-0611 |
| Popis: | Chemical investigation of the stems of Dulacia egleri resulted in the isolation of eglerisine (1), a compound with a rare sesquiterpenoid tropolone skeleton. Its structure was determined by analysis of spectrometric and spectroscopic data, including HRESIMS, 1D, and 2D NMR. The antiproliferative effects of eglerisine were tested in human leukemia lineages. In the Kasumi-1 lineage, an acute myeloid leukemia cell line, eglerisine reduced cell metabolism, as determined by the resazurin assay. Eglerisine did not induce cell death by either apoptotic or necrotic mechanisms. However, a reduction of the absolute number of cells was observed. Eglerisine induced cell cycle arrest after 72 h of treatment by phosphorylation of H2AX histone, reducing the S phase and increasing the G2 phase of the cell cycle. |
| Databáze: | OpenAIRE |
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