Intracortical inhibition of the motor cortex is normal in chorea
| Autor: | Katsuyuki Machii, Toshiaki Furubayashi, Yasushi Shiio, Ichiro Kanazawa, Yasuo Terao, Yoshikazu Ugawa, Haruo Uesugi, Hitoshi Mochizuki, Hiroyuki Enomoto, Ritsuko Hanajima |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pathology Parkinson's disease genetic structures Short Report Central nervous system disease Lesion Internal medicine mental disorders medicine Chorea acanthocytosis Putamen Chorea medicine.disease humanities nervous system diseases Psychiatry and Mental health Endocrinology medicine.anatomical_structure Globus pallidus Surgery Neurology (clinical) medicine.symptom Psychology Motor cortex |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 66:783-786 |
| ISSN: | 0022-3050 |
| Popis: | Intracortical inhibition of the motor cortex was investigated using a paired pulse magnetic stimulation method in 14 patients with chorea caused by various aetiologies (six patients with Huntington's disease, one with chorea acanthocytosis, a patient with systemic lupus erythematosus with a vascular lesion in the caudate, three with senile chorea and three with chorea of unknown aetiology). The time course and amount of inhibition was the same in the patients as in normal subjects, suggesting that the inhibitory mechanisms of the motor cortex studied with this method are intact in chorea. This is in striking contrast with the abnormal inhibition seen in patients with Parkinson's disease or focal hand dystonia, or those with a lesion in the putamen or globus pallidus. It is concluded that the pathophysiological mechanisms responsible for chorea are different from those producing other involuntary movements. |
| Databáze: | OpenAIRE |
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