Loss of epithelial differentiation markers and acquisition of vimentin expression after xenograft with laminin-1 enhance migratory and invasive abilities of human colon cancer cells LoVo C5
| Autor: | Claire Bellaton, Lionel Remy, Jérôme Dumortier, Suzanne Bertrand, Celine Pourreyron, Marie-France Jacquier, Daemi N, Wena Anderson, Jean-Alain Chayvialle |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Transplantation Heterologous Vimentin Adenocarcinoma Cell Movement Laminin medicine Animals Humans Neoplasm Invasiveness Collagenases Molecular Biology Basement membrane Matrigel biology Mesenchymal stem cell Metalloendopeptidases Cell Differentiation Epithelial Cells Cell Biology Molecular biology In vitro Rats Phenotype medicine.anatomical_structure Matrix Metalloproteinase 9 Gelatinases Cell culture Colonic Neoplasms Immunology biology.protein Matrix Metalloproteinase 2 Clone (B-cell biology) Neoplasm Transplantation Developmental Biology |
| Zdroj: | Differentiation. 63:141-150 |
| ISSN: | 0301-4681 |
| DOI: | 10.1046/j.1432-0436.1998.6330141.x |
| Popis: | Clone C5 of the the human colon adenocarcinoma LoVo cell line was subcutaneously injected with or without exogenous laminin-1 (EHS laminin) into immunosuppressed newborn rats. Cultures were initiated from lung metastases obtained with or without laminin-1 and gave rise to the C5 sublines LM and M4, respectively. The LM subline was mainly composed of spreading cells whereas most C5 and M4 cells remained round and aggregated. The mesenchymal marker vimentin was expressed by very rare C5 and M4 cells ( |
| Databáze: | OpenAIRE |
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