STUDIES ON VIRAL INHIBITORS OF BIOLOGICAL ORIGIN. I. INHIBITION OF VIRAL REPLICATION BY PROTEIN-LIKE CONSTITUENTS OF BACTERIA
| Autor: | David H. Carver, Kiarash Naficy |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Salmonella typhimurium
viruses Adenoviridae Infections Vaccinia virus Corynebacterium medicine.disease_cause Virus Replication Antiviral Agents General Biochemistry Genetics and Molecular Biology Virus Microbiology Adenoviridae chemistry.chemical_compound Ribonucleases Bacterial Proteins Viral entry medicine Escherichia coli Simplexvirus Trypsin Viral shedding Pharmacology Deoxyribonucleases biology Corynebacterium diphtheriae Research DNA biology.organism_classification Virology Enterovirus B Human Enterovirus C Human Encephalitis Viruses Poliovirus chemistry Viral replication Bacteria Arboviruses medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 116 |
| ISSN: | 0037-9727 |
| Popis: | SummaryViral inhibitory factors were isolated from several different bacterial species including representatives of both gram negative and positive groups. Two of the factors were found to prevent viral cytopathogenicity even when added as late as 18 hours after viral inoculation. Trypsin sensitivity indicates that these inhibitors are probably proteins. Evidence is presented that viral inhibition appears to occur during the intra-cellular stages of viral replication. Each factor has a sharply specific spectrum of antiviral activity. This specificity of action may reflect blocking of cellular metabolic pathways necessary only for the replication of the virus affected. |
| Databáze: | OpenAIRE |
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