Targeted neurotechnology restores walking in humans with spinal cord injury
| Autor: | Jocelyne Bloch, Ismael Seáñez, Elvira Pirondini, Marco Capogrosso, Nicholas Buse, Joachim von Zitzewitz, Molywan Vat, Laura A. McCracken, Andreas Rowald, Fabio Becce, Fabien Wagner, Miroslav Caban, Timothy J. Denison, Robin Demesmaeker, Isabelle Fodor, Edoardo Paoles, Brigitte Schurch, Rik Buschman, Roman Heimgartner, Hendrik Lambert, Niels Kuster, Esra Neufeld, Etienne Pralong, Grégoire Courtine, Katrien Van Den Keybus, Anne Watrin, Stefano Carda, John O. Prior, Jean-Baptiste Mignardot, Karen Minassian, Camille Georgette Marie Le Goff-Mignardot, Grégoire Eberle, Salif Komi, Perrine Seguin, Vincent Delattre |
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| Přispěvatelé: | Ecole Polytechnique Fédérale de Lausanne (EPFL), University of Fribourg, GTX medical, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Medtronic, Minneapolis, Medtronic, Foundation for Research on Information Technologies in Society (IT’IS) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Multidisciplinary Rehabilitation medicine.diagnostic_test business.industry medicine.medical_treatment [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Stimulation Electromyography medicine.disease Neuromodulation (medicine) Epidural space 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Physical medicine and rehabilitation medicine.anatomical_structure Neurotechnology medicine Paralysis medicine.symptom business Spinal cord injury 030217 neurology & neurosurgery |
| Zdroj: | Nature Nature, Nature Publishing Group, 2018, 563 (7729), pp.65-71. ⟨10.1038/s41586-018-0649-2⟩ Nature, 563 (7729) |
| ISSN: | 0028-0836 1476-4679 |
| DOI: | 10.1038/s41586-018-0649-2 |
| Popis: | International audience; Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective stimulation to the lumbosacral spinal cord with timing that coincided with the intended movement. Within one week, this spatiotemporal stimulation had re-established adaptive control of paralysed muscles during overground walking. Locomotor performance improved during rehabilitation. After a few months, participants regained voluntary control over previously paralysed muscles without stimulation and could walk or cycle in ecological settings during spatiotemporal stimulation. These results establish a technological framework for improving neurological recovery and supporting the activities of daily living after spinal cord injury. |
| Databáze: | OpenAIRE |
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