Molecular regulation of tooth development
| Autor: | Irma Thesleff, Thomas Åberg |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Mineralized tissues
Histology Physiology Endocrinology Diabetes and Metabolism Cementoblast Biology Epithelium Mesoderm Embryonic and Fetal Development Mice 03 medical and health sciences 0302 clinical medicine stomatognathic system Cell–cell interaction Morphogenesis medicine Animals Cementum Dental alveolus 030304 developmental biology 0303 health sciences 030206 dentistry Anatomy Neoplasm Proteins Cell biology stomatognathic diseases Odontoblast medicine.anatomical_structure Ameloblast Tooth Signal Transduction Transcription Factors |
| Zdroj: | Bone. 25:123-125 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/s8756-3282(99)00119-2 |
| Popis: | Teeth are organs that are only found in the oral cavity of vertebrates. Although they are composed of mineralized tissues and they are attached to bone, they do not form as outgrowths of bone. In fact, tooth development starts in the embryonic oral epithelium well before bone formation, and osteogenesis of the alveolar bone is later regulated by the teeth rather than vice versa. The mineralizing extracellular matrices of teeth, the enamel, dentine, and cementum, are formed by the ameloblasts, odontoblasts, and cementoblasts, respectively, which are unique dental cell types differentiating during specific stages of tooth morphogenesis. Teeth are typical examples of epithelial appendages, i.e., organs that develop from surface epithelium and underlying mesenchymal tissue. Interactions between the epithelial and mesenchymal tissues regulate the development of all epithelial appendages. These interactions, originally discovered in classic tissue recombination studies, are reciprocal and occur sequentially, constituting a kind of discussion between the neighboring tissues. The molecules of the signaling networks that mediate these interactions started to be elucidated in the late 1980s, and it has become apparent that same signaling molecules regulate the development in all epithelial appendages. Teeth belong to those organs in which the signaling mechanisms have been actively analyzed in the 1990s. |
| Databáze: | OpenAIRE |
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