Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice
| Autor: | B. Prado, C.C. Sánchez-Mateo, C.X. Bonkanka, R. M. Rabanal |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Tetrabenazine Pharmacology Pharmacognosy Chemical Fractionation Motor Activity Body Temperature 5-Hydroxytryptophan chemistry.chemical_compound Mice Animal models of depression Drug Discovery medicine Animals Blepharoptosis Hypnotics and Sedatives Pentobarbital biology Traditional medicine business.industry Plant Extracts Butanol Hypericum perforatum Plant Components Aerial biology.organism_classification Antidepressive Agents chemistry lipids (amino acids peptides and proteins) Female business Hypericum Sleep medicine.drug Behavioural despair test |
| Zdroj: | Journal of ethnopharmacology. 112(1) |
| ISSN: | 0378-8741 |
| Popis: | We previously reported that oral administration of the methanol extract obtained from the aerial part in blossom of Hypericum reflexum L. fil. was active in the tetrabenazine and forced swimming test. In the present study, the effect of the aqueous, butanol and chloroform fractions obtained from the methanol extract of this species on the central nervous system was investigated in mice, particularly in animal models of depression. Antidepressant activity was detected in the butanol and chloroform fractions of this species using the forced swimming test since both fractions induced a significant reduction of the immobility time, producing no effects or only a slight depression on spontaneous motor activity when assessed in a photocell activity meter. Moreover, these fractions did not alter significantly the pentobarbital-induced sleeping time. On the other hand, the chloroform fraction produced a slight but significant hypothermia and was also effective in antagonizing the ptosis induced by tetrabenazine. Furthermore, the butanol fraction produced a slight potentiation of the head twitches and syndrome induced by 5-HTP. Taken together, these data indicate that the butanol and chloroform fractions from Hypericum reflexum possess antidepressant-like effects in mice, providing further support for the traditional use of these plants in the Canary Islands folk medicine against central nervous disorders. |
| Databáze: | OpenAIRE |
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