Acute kidney injury is an independent predictor of in-hospital mortality in a general medical ward: A retrospective study from a tertiary care centre in south India

Autor:	Murugabharathy Kalimuthu, Vignesh Kumar Chandiraseharan, Visalakshi Jayaseelan, Turaka Vijay Prakash, Thambu David Sudarsanam, Tina George, Ashwin Rajenesh
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty lcsh:Medicine India urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Tertiary Care Centers Risk Factors Intensive care Medicine Humans Hospital Mortality Prospective Studies Risk factor acute kidney injury - in-hospital - mortality - risk factors Prospective cohort study Retrospective Studies Univariate analysis business.industry Mortality rate lcsh:R Acute kidney injury Retrospective cohort study General Medicine Odds ratio Acute Kidney Injury medicine.disease mortality female genital diseases and pregnancy complications Emergency medicine Original Article in-hospital business
Zdroj:	The Indian Journal of Medical Research Indian Journal of Medical Research, Vol 152, Iss 4, Pp 386-392 (2020)
ISSN:	0975-9174 0971-5916
Popis:	Background & objectives: Acute kidney injury (AKI) has been identified as an independent risk factor for mortality in intensive care units. This retrospective study was conducted to determine the effect of AKI on in-hospital mortality in a general medical ward of a tertiary care hospital and risk factors for mortality in patients with AKI. Methods: Demographic and clinical details, and outcome data were collected from case records of patients. In all hospitalized patients, factors associated with increased in-hospital mortality, such as AKI, inotrope requirement, mechanical ventilation and primary disease were compared between patients who died during their hospital stay and those who were discharged alive. Among the hospitalized patients, who had AKI, likely predictors of in-hospital mortality were compared between dead and alive patients at discharge. Factors that were significant in univariate analysis were tested by multivariate regression analysis to identify those that independently predicted poor outcomes. Results: Of the 1150 patients admitted in a general medical ward in a year, 220 patients were identified to have AKI. In-hospital mortality rate among patients with AKI was 19.09 per cent as compared to 1.8 per cent without AKI [adjusted odds ratio (OR) 5.7 (95% CI: 1.56-20.74)]. The presence of AKI was an independent risk factor for death, with an adjusted OR of 6.0 [95% CI: 1.67-21.6]. Among patients with AKI, the presence of haematological malignancy, adjusted OR 25.86 (95% CI: 1.81-369.58), requirement of inotrope, adjusted OR 126.5 (95% CI: 19.39-825.93) and serum creatinine at admission (P
Databáze:	OpenAIRE
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