Outdoor artificial light at night and risk of non-Hodgkin lymphoma among women in the California Teachers Study cohort
| Autor: | Charlie Zhong, Joseph L. Wiemels, Roberta McKean-Cowdin, Sophia S. Wang, Travis Longcore, James V. Lacey, Meredith Franklin, Nadia T. Chung, Jennifer L. Benbow |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Light Epidemiology Follicular lymphoma Article Cohort Studies 03 medical and health sciences 0302 clinical medicine immune system diseases Risk Factors Internal medicine hemic and lymphatic diseases medicine Humans 030212 general & internal medicine Prospective Studies business.industry Proportional hazards model Lymphoma Non-Hodgkin Hazard ratio medicine.disease Lymphoma Cancer registry 030220 oncology & carcinogenesis Cohort Female business Body mass index Cohort study |
| Zdroj: | Cancer Epidemiol |
| ISSN: | 1877-783X |
| Popis: | Background Outdoor artificial light at night (ALAN) has been implicated in a growing number of adverse health outcomes. ALAN is believed to disrupt circadian rhythms and has been associated with increased inflammation, one of the hallmarks of cancer. We examined the association between outdoor ALAN and a cancer strongly associated with autoimmune and inflammatory conditions, non-Hodgkin lymphoma (NHL), in the prospective California Teachers Study cohort. Methods Outdoor ALAN was assigned to participant addresses at study baseline (1995−96) through use of the New World Atlas of Artificial Night Sky Brightness. Among 105,937 women followed from 1995 to 2015, linkage to the California Cancer Registry identified 873 incident cases of NHL. Age-stratified Cox proportional hazards models were used to calculate hazard ratios (HR) and 95 % confidence intervals (95 %CI) for overall NHL and the most common NHL subtypes; diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Multivariate analyses adjusted for previously reported subtype specific covariates (e.g. body mass index (BMI) for DLBCL). Results Compared to the lowest quintile, participants residing in the highest quintile of outdoor ALAN at baseline were more likely to develop NHL (HR = 1.32, 95 %CI = 1.07−1.63), and, in particular, DLBCL (HR = 1.87, 95 %CI = 1.16−3.02). The elevated risk for DLBCL remained statistically significant after adjusting for age, race/ethnicity, BMI, and socioeconomic status (DLBCL:HR = 1.87, 95 %CI = 1.16−3.02, NHL:HR = 1.32, 95 %CI = 1.07−1.63). There was no association between ALAN and FL or CLL/SLL. Conclusion DLBCL risk was elevated among women residing in neighborhoods with greater outdoor ALAN. Future research in circadian disruption and DLBCL may clarify potential biological processes implicated in this association. |
| Databáze: | OpenAIRE |
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