ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier
| Autor: | Giulio Sancini, P Gasco, Roberta Rigolio, C Musicanti, R Dal Magro, Francesca Re, Elisabetta Donzelli, Elisa Ballarini, Guido Cavaletti, F Ornaghi, Annalisa Canta, Ilaria Cambianica, S Beretta |
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| Přispěvatelé: | DAL MAGRO, R, Ornaghi, F, Cambianica, I, Beretta, S, Re, F, Musicanti, C, Rigolio, R, Donzelli, E, Canta, A, Ballarini, E, Cavaletti, G, Gasco, P, Sancini, G |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Male BALB 3T3 Cells Surface Properties Pharmaceutical Science Peptide 02 engineering and technology Pharmacology Blood–brain barrier Cell Line Capillary Permeability 03 medical and health sciences Mice Apolipoproteins E Drug Delivery Systems BIO/09 - FISIOLOGIA Solid lipid nanoparticle medicine Animals chemistry.chemical_classification Drug Carriers Chemistry 021001 nanoscience & nanotechnology Solid lipid nanoparticles ApoE-derived peptide pulmonary administration brain targeting blood-brain barrier Lipid Metabolism Lipids Bioavailability 030104 developmental biology medicine.anatomical_structure Blood-Brain Barrier Drug delivery Surface modification Nanoparticles Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 249 |
| ISSN: | 1873-4995 |
| Popis: | Solid lipid nanoparticles (SLN) are colloidal drug delivery systems characterized by higher entrapment efficiency, good scalability of the preparation process and increased sustained prolonged release of the payload compared to other nanocarriers. The possibility to functionalize the surface of SLN with ligands to achieve a site specific targeting makes them attractive to overcome the limited blood-brain barrier (BBB) penetration of therapeutic compounds. SLN are prepared for brain targeting by exploiting the adaptability of warm microemulsion process for the covalent surface modification with an Apolipoprotein E-derived peptide (SLN-mApoE). Furthermore, the influence of the administration route on SLN-mApoE brain bioavailability is here evaluated. SLN-mApoE are able to cross intact a BBB in vitro model. The pulmonary administration of SLN-mApoE is related to a higher confinement in the brain of Balb/c mice compared to the intravenous and intraperitoneal administration routes, without inducing any acute inflammatory reaction in the lungs. These results promote the pulmonary administration of brain-targeted SLN as a feasible strategy for improving brain delivery of therapeutics. |
| Databáze: | OpenAIRE |
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