Disposition of exogenous tritium-labelled GM1lactone in the rat
| Autor: | E. Facchinetti, F. Milan, P. Bellato, G. Toffano |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Time Factors Stereochemistry G(M1) Ganglioside Tritium Injections Intramuscular Rats Sprague-Dawley Cellular and Molecular Neuroscience Pharmacokinetics Animals Tissue Distribution Open form Chromatography High Pressure Liquid Cerebral Cortex Ganglioside Chemistry Radiochemistry Brain Cell Biology Disposition Prodrug Bioavailability Rats carbohydrates (lipids) Sprague dawley Injections Intravenous lipids (amino acids peptides and proteins) |
| Zdroj: | Neurochemistry international. 20(3) |
| ISSN: | 0197-0186 |
| Popis: | The disposition of labelled [3H]GM1lactone, the inner ester of ganglioside GM1, was studied in the rat. After i.v. administration [3H]GM1lactone was quickly converted to its corresponding open form most likely by plasma esterases, and then displayed a pharmacokinetic profile identical to [3H]GM1. Following intramuscular administration of [3H]GM1lactone [3H]GM1 levels in plasma and in tissues were higher than those obtained after the administration of an equivalent dose of [3H]GM1. This increased bioavailability means that GM1lactone can be considered as a potential prodrug of GM1. |
| Databáze: | OpenAIRE |
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