Cerebral Micro-Structural Changes in COVID-19 Patients – An MRI-based 3-month Follow-up Study
| Autor: | Yiping Lu, Dongdong Wang, Chu Chung Huang, Nan Mei, Bo Yin, Tianye Jia, Pu Yeh Wu, Yajing Zhao, Daoying Geng, Anling Xiao, Xuanxuan Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus-2 RD Radial Diffusivity TE Echo Time UF Uncinate Fasciculus 01 natural sciences HIV Human Immunodeficiency Virus CR Corona Radiata 0302 clinical medicine Gyrus Central Nervous System Diseases 3D-T1WI 3 Dimensional T1-weighted Images PCR Polymerase Chain Reaction 030212 general & internal medicine GMV Gray Matter Volume Prospective cohort study lcsh:R5-920 CSF Cerebral Spinal Fluid WBC White Blood Cell GM Gray Matter General Medicine OB Olfactory Bulb ACE-2 Angiotensin Converting Enzyme-2 CNS Central Nervous System MD Mean Diffusivity TR Repetition Time medicine.anatomical_structure Diffusion Tensor Imaging WMV White Matter Volume lcsh:Medicine (General) FOV Field of View DTI Diffusion Tensor Imaging AD Axial Diffusivity JEV Japanese Encephalitis Virus Uncinate fasciculus Neuroimaging WM White Matter Article WHO World Health Organization MPRAGE Magnetization Prepared Rapid Gradient Echo White matter 03 medical and health sciences Fractional anisotropy DICOM Digital Imaging and Communications in Medicine medicine AAL-3 Automated Anatomical Labelling Atlas-3 SARS-CoV Severe Acute Respiratory Syndrome Coronavirus 0101 mathematics SFF Superior Frontal-occipital Fasciculus VBM Voxel-based Morphometry LDH Lactate Dehydrogenase URTI Upper Respiratory Tract Infection FA Fractional Anisotropy business.industry TBSS Track-based Spatial Statistics 010102 general mathematics COVID-19 COVID-19 Coronavirus Disease Voxel-based morphometry EC External Capsule HSV Herpes Simplex Virus business Nuclear medicine Prospective studies Diffusion MRI |
| Zdroj: | EClinicalMedicine, Vol 25, Iss, Pp 100484-(2020) EClinicalMedicine |
| ISSN: | 2589-5370 |
| Popis: | Background: Increasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We aimed to identify the existence of potential brain micro-structural changes related to SARS-CoV-2. Methods: In this prospective study, diffusion tensor imaging (DTI) and 3D high-resolution T1WI sequences were acquired in 60 recovered COVID-19 patients (56.67% male; age: 44.10 ± 16.00) and 39 age- and sex-matched non-COVID-19 controls (56.41% male; age: 45.88 ± 13.90). Registered fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were quantified for DTI, and an index score system was introduced. Regional volumes derived from Voxel-based Morphometry (VBM) and DTI metrics were compared using analysis of covariance (ANCOVA). Two sample t-test and Spearman correlation were conducted to assess the relationships among imaging indices, index scores and clinical information. Findings: In this follow-up stage, neurological symptoms were presented in 55% COVID-19 patients. COVID-19 patients had statistically significantly higher bilateral gray matter volumes (GMV) in olfactory cortices, hippocampi, insulas, left Rolandic operculum, left Heschl's gyrus and right cingulate gyrus and a general decline of MD, AD, RD accompanied with an increase of FA in white matter, especially AD in the right CR, EC and SFF, and MD in SFF compared with non-COVID-19 volunteers (corrected p value |
| Databáze: | OpenAIRE |
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